Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

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Basse-O'Connor, A., Overgaard, T. L. & Rasmussen, M. M. S. (2025). Some Results on Random Mixed SAT Problems. In A. Srakar (Ed.), 23rd European Young Statisticians Meeting: 11.-15. September 2023, Ljubljana, Slovenia: Proceedings (pp. 113-118). Article 19 Statistical Society of Slovenia. https://plus.cobiss.net/cobiss/si/sl/data/cobib/213542659

Nielsen, K. H. (2025). Storbyens rotteræs. Weekendavisen, Sektion 4 (Ideer), 5.

Rotilio, L., Bayer, T., Meinert, H., Teixeira, L. M. C., Johansen, M. B., Sommerfeldt, A., Petersen, A. R., Sandahl, A., Keller, M. B., Holck, J., Paiva, P., Otzen, D. E., Bornscheuer, U. T., Wei, R., Fernandes, P. A., Ramos, M. J., Westh, P. & Morth, J. P. (2025). Structural and Functional Characterization of an Amidase Targeting a Polyurethane for Sustainable Recycling. Angewandte Chemie International Edition, 64(7), Article e202419535. https://doi.org/10.1002/anie.202419535

Singh, P., Kadam, N. Y., Panigrahi, R., Mehrotra, A., Upadhayay, K., Dey, M., Tyagi, A., Aquib, M., Nielsen, J., Kleijwegt, G., Singh, P., Sharma, A., Rao, A., Otzen, D. E., Kumar, A. & Sharma, D. (2025). Sulfamerazine as a Potential Modulator against α-Synuclein Aggregation and Associated Toxicity. ACS Chemical Neuroscience, 16(5), 880-894. https://doi.org/10.1021/acschemneuro.4c00803

Sønderskov, S. M., Klausen, L. H., Skaanvik, S. A., Han, X. & Dong, M. (2025). Super-resolution imaging with nanopipettes. NPJ Imaging, 3(1), Article 46. https://doi.org/10.1038/s44303-025-00108-9

Tang, A. A., Gobry, M. V., Li, S., Andersen, E. S. & Franco, E. (2025). Switchable RNA motifs for dynamic transcriptional control of RNA condensates. Nucleic Acids Research, 53(12), Article gkaf497. https://doi.org/10.1093/nar/gkaf497

Irla, M., Nærdal, I., Virant, D., Brautaset, T., Busche, T., Goranovič, D., Haupka, C., Heux, S., Kosec, G., Rückert-Reed, C., Wendisch, V. F., Brito, L. F. & Vicente, C. M. (2025). Systems-level analysis provides insights on methanol-based production of L-glutamate and its decarboxylation product γ-aminobutyric acid by Bacillus methanolicus. Metabolic Engineering, 91, 389-404. https://doi.org/10.1016/j.ymben.2025.06.002

Hu, J., Liu, Q., Ouyang, Y., Dong, M., Luo, B. & Zhang, X. (2025). Tailoring Membrane Surface Electrostatics to Regulate Zinc Deposition for Alkaline Zinc-Based Flow Battery. ACS Energy Letters, 10, 6408-6414. https://doi.org/10.1021/acsenergylett.5c03091

Ju, X., Chen, C., Oral, C. M., Sevim, S., Golestanian, R., Sun, M., Bouzari, N., Lin, X., Urso, M., Nam, J. S., Cho, Y., Peng, X., Landers, F. C., Yang, S., Adibi, A., Taz, N., Wittkowski, R., Ahmed, D., Wang, W. ... Pumera, M. (2025). Technology Roadmap of Micro/Nanorobots. ACS Nano, 19(27), 24174-24334. https://doi.org/10.1021/acsnano.5c03911

Zaheer, S., Baindoor, S., Connolly, N. M. C., Siebenbrodt, K., Bauer, S., Rosenow, F., Andersen, J. S., Venø, M. T., Kjems, J., Henshall, D. C. & Prehn, J. H. M. (2025). Temporal Dynamics of tsRNA Regulation Mark an Abrupt Transition After Epileptogenesis. Journal of Neurochemistry, 169(12), Article e70317. https://doi.org/10.1111/jnc.70317

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