Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Jensen, T. H., Rosbash, M. & Andersen, E. S. (2003). Co-transcriptional monitoring of mRNP formation. Nature Structural and Molecular Biology, 10(1), 10-12.

Jensen, A.-M., Finster, K. & Karlson, U. (2003). Degradation of carbazole, dibenzothiophene, and dibenzofuran at low temperature by Pseudomonas sp. strain C3211. Environmental Toxicology and Chemistry, 22(4), 730-735.

Andersen, E. S., Jeeninga, R. E., Damgaard, C. K., Berkhout, B. & Kjems, J. (2003). Dimerization and template switching in the 5' untranslated region between various subtypes of human immunodeficiency virus type 1. Journal of Virology, 77(5), 3020-30. https://doi.org/10.1128/JVI.77.5.3020-3030.2003

Middelboe, M., Glud, R. N. & Finster, K. (2003). Distribution of viruses and bacteria in relation to diagenetic activity in an estuarine sediment. Limnology and Oceanography, 48(4), 1447-1456.

Jensen, T. H., Dower, K., Libri, D., Rosbash, M. & Andersen, E. S. (2003). Early formation of mRNP: license for export or quality control? Mol. Cell., 11(5), 1129-38.

Deplancke, B., Finster, K., Graham, W. V., Collier, C. T., Thurmond, J. E. & Gaskins, H. R. (2003). Gastrointestinal and microbial responses to sulfate-supplemented drinking water in mice. Intestinal and Microbial Repsonses to SO42, 424-433.

Langer, J. W. & Andersen, E. S. (2003). Hallas-Møller Stipendium 2003. Udforsker genernes ′stik-i-rend dreng′. In Novo Nordisk Årsskrift 2003

Hornekær, L., Baurichter, A., Petrunin, V. V., Field, D. & Luntz, A. (2003). Importance of SurfaceMorphology in Interstellar H₂ Formation. Science, 302, 1943.

Bostrup, L. & Andersen, E. S. (2003). Maren og myrerne. Aktuel Naturvidenskab, (6).

Hansen, N. & Andersen, E. S. (2003). Når journalisten ringer ... Aktuel Naturvidenskab, (5).

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