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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Jørgensen, A. G., Kristoffersen, E. L., Petersen, K. V., Ho, Y.-P., Stougaard, M. & Knudsen, B. R. (2016). Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons. Sensors, 16(11), Article 1916. https://doi.org/10.3390/s16111916

Zhang, Y., Lynge, M. E., Nielsen, M., Schattling, P., Han, X. & Stadler, B. M. (2016). Patterned Liposome–Polymer Composite Coatings. ChemNanoMat, 2(8), 822-829. https://doi.org/10.1002/cnma.201600022

Lou, C., Martos-Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, N. J., Kjems, J., Thulstrup, P. W., Wengel, J. & Jensen, K. J. (2016). Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic. Nature Communications, 7, Article 12294. https://doi.org/10.1038/ncomms12294

Nielsen, K. H. (2016). Plast. Weekendavisen, Ideer, 10.

Andersen, A. S., Aslan, H., Dong, M., Jiang, X. & Sutherland, D. (2016). Podosome formation and development in monocytes restricted by the nanoscale spatial distribution of ICAM1. Nano Letters, 16(3), 2114-2121. https://doi.org/10.1021/acs.nanolett.6b00519

Hinton, T. M., Zuwala, K., Deffrasnes, C., Todd, S., Shi, S., Marsh, G. A., Dearnley, M., Wohl, B. M., Tolstrup, M. & Zelikin, A. N. (2016). Polyanionic Macromolecular Prodrugs of Ribavirin: Antiviral Agents with a Broad Spectrum of Activity. Advanced Healthcare Materials, 5(5), 534-540. https://doi.org/10.1002/adhm.201500841

Jensen, B. E. B., Davila, I. & Zelikin, A. N. (2016). Poly(vinyl alcohol) Physical Hydrogels: Matrix-Mediated Drug Delivery Using Spontaneously Eroding Substrate. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 120(26), 5916-5926. https://doi.org/10.1021/acs.jpcb.6b01381

Frick, M., Fischer, J., Helbing, A., Ruëff, F., Wieczorek, D., Ollert, M., Pfützner, W., Müller, S., Huss-Marp, J., Dorn, B., Biedermann, T., Lidholm, J., Rücker, G., Bantleon, F., Miehe, M., Spillner, E. & Jakob, T. (2016). Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy. Journal of Allergy and Clinical Immunology, 138(6), 1663-1671.e9. https://doi.org/10.1016/j.jaci.2016.04.024

Wang, J.-G., Jin, L.-N., Qian, X.-Y. & Dong, MD. (2016). Preparation and Catalytic Activity Comparison of Porous NiO, Co3O4 and NiCo2O4 Superstructures on the Thermal Decomposition of Ammonium Perchlorate. Journal of Nanoscience and Nanotechnology, 16(8), 8635-8639. https://doi.org/10.1166/jnn.2016.11635

Cheng, W., He, J., Chen, M., Li, D., Li, H., Chen, L., Cao, Y., Wang, J. & Huang, Y. (2016). Preparation, functional characterization and hemostatic mechanism discussion for oxidized microcrystalline cellulose and its composites. Fibers and Polymers, 17(8), 1277-1286. https://doi.org/10.1007/s12221-016-6279-0

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Kalinka Hansen