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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Ghodke, S., Nielsen, S. B., Christiansen, G., Hjuler, H. A., Flink, J., Otzen, D. & Nielsen, S. B. (2012). Mapping out the multistage fibrillation of glucagon. FEBS journal, 279(5), 752-765. https://doi.org/10.1111/j.1742-4658.2011.08465.x

Asmussen, S. & Hobolth, A. (2012). Markov bridges, bisection and variance reduction. In L. Plaskota & H. Wozniakowski (Eds.), Monte Carlo and Quasi-Monte Carlo Methods 2010 (pp. 3-22). Springer. https://doi.org/10.1007/978-3-642-27440-4_1

Temkiv, T. S., Finster, K. & Gosewinkel, U. B. (2012). Metagenomics of clouds and atmosphere. In Encyclopedia of Metagenomics Springer Science+Business Media.

Poulsen, H. V., Jensen, B. B., Finster, K., Spence, C., Whitehead, T. R., Cotta, M. A. & Canibe, N. (2012). Microbial production of volatile sulphur compounds in the large intestine of pigs fed two different diets. Journal of Applied Microbiology, 113(1), 143-154. https://doi.org/10.1111/j.1365-2672.2012.05309.x

Bellemer, C., Bortolin-Cavaillé, M.-L., Schmidt, U., Jensen, S. M. R., Kjems, J., Bertrand, E. & Cavaillé, J. (2012). Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes. Journal of Cell Science, 125, 2709-2720 . https://doi.org/10.1242/jcs.100354

Montanini, L., Lasagna, L., Barili, V., Jonstrup, S. P., Murgia, A., Pazzaglia, L., Conti, A., Novello, C., Kjems, J., Perris, R. & Benassi, M. S. (2012). MicroRNA cloning and sequencing in osteosarcoma cell lines:differential role of miR-93. Cellular Oncology (Dordrecht), 35(1), 29-41. https://doi.org/10.1007/s13402-011-0059-z

Novotny, G. W., Belling, K. C., Bramsen, J. B., Nielsen, J. E., Bork-Jensen, J., Almstrup, K., Sonne, S. B., Kjems, J., Rajpert-De Meyts, E. & Leffers, H. (2012). MicroRNA expression profiling of carcinoma in situ (CIS) cells of the testis. Endocrine-Related Cancer, 365-379. https://doi.org/10.1530/ERC-11-0271

Chen, D., Liu, B., Gao, F. & Dong, M. (2012). Migration of point defects and a defect pair in zinc oxide using the dimer method. Journal of Materials Research, 27(17), 2241-2248. https://doi.org/10.1557/jmr.2012.153

Andreasen, M., Nielsen, S. B., Mittag, T., Bjerring, M., Nielsen, J. T., Zhang, S., Nielsen, E. H., Jeppesen, M., Christiansen, G., Besenbacher, F., Dong, M., Nielsen, N. C., Skrydstrup, T. & Otzen, D. E. (2012). Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone. Biochimica et Biophysica Acta - Proteins and Proteomics, 1824(2), 274-85. https://doi.org/10.1016/j.bbapap.2011.10.014

Kristensen, M. V., Ahrendt, P., Lindballe, T. B., Nielsen, O. H. A., Kylling, A. P., Karstoft, H., Imparato, A., Rigau, L. H., Stadler, B., Stapelfeldt, H. & Keiding, S. R. (2012). Motion analysis of optically trapped particles and cells using 2D Fourier analysis. Optics Express, 20(3), 1953-1962. https://doi.org/10.1364/OE.20.001953

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Kalinka Hansen