Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

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Nielsen, K. H. (2017). Viden. Aarhus Universitetsforlag. Tænkepauser - viden til hverdagen Vol. 46

Zhang, Z., Xu, R., Wang, Z., Dong, M., Cui, B. & Chen, M. (2017). Visible Light Neural Stimulation on graphitic-Carbon Nitride/Graphene Photocatalytic Fibers. A C S Applied Materials and Interfaces, 9(40), 34736–34743. https://doi.org/10.1021/acsami.7b12733

Engholm, D. H., Goodsell, D., Kilian, M., Andersen, E. S., Pedersen, B. P. & Kjærgaard, R. S. (2017). Visualising the bacterium Streptococcus Pneumoniae. In L. Philipsen & R. Schmidt Kjærgaard (Eds.), The Aesthetics of Scientific Data Representation: More than Pretty Pictures Routledge. https://www.routledge.com/The-Aesthetics-of-Scientific-Data-Representation-More-than-Pretty-Pictures/Philipsen-Schmidt-Kjaergaard/p/book/9781138679375

Engholm, D. H., Goodsell, D., Kilian, M., Andersen, E. S., Pedersen, B. P. & Kjærgaard, R. S. (2017). Visualizing the Bacterium Streptococcus pneumoniae. In L. Philipsen & R. Schmidt Kjærgaard (Eds.), The Aesthetics of Scientific Data Representation: More than Pretty Pictures (1. ed. ed., pp. 1-15). Routledge. https://doi.org/10.4324/9781315563411

Bak, E. N., Goul, M., Rasmussen, M., Moeller, R., Nørnberg, P., Jensen, S. K. & Finster, K. (2017). Wind driven saltation: a hitherto overlooked challenge for life on Mars. Abstract from EGU 2017, Wien, Austria.

van Diggelen, F., Tepper, A., Petri, M. & Otzen, D. (2017). α-Synuclein Oligomers: A Study in Diversity. Israel Journal of Chemistry, 57(7), 699-723. https://doi.org/10.1002/ijch.201600116

Nielsen, K. H. (2016). 1922 Atomet. In Danmark bliver moderne 1900-1950 Aarhus Universitetsforlag.

Nielsen, K. H. (2016). 1929 TV. In Danmark bliver moderne 1900-1950 Aarhus Universitetsforlag.

Nielsen, K. H. (2016). 1929 Universet. In Danmark bliver moderne 1900-1950 Aarhus Universitetsforlag.

Xu, R. & Chen, M. (2016). 3D Mechanical Environment and Chemical Cues Influence HUMC Fibroblast Differentiation and Fibroblast-To-Myofbiroblast Transition. Poster session presented at Advances in Cell Engineering, Imaging and Screening: VIB tools and technologies, Leuven, Belgium.

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