Find

AUNAB - Aarhus University Network on Artificial Biology

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

Sort by: Date | Author | Title

Civit, L., Moradzadeh, N., Jonczyk, A., Neckermann, P., Asbach, B., Peterhoff, D., Wagner, R., Famulok, M., Mayer, G., Kjems, J. & Valero, J. (2024). A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein. International Journal of Molecular Sciences , 25(9), Article 4642. https://doi.org/10.3390/ijms25094642

Dinesen, A., Andersen, V. L., Elkhashab, M., Pilati, D., Bech, P., Fuchs, E., Samuelsen, T. R., Winther, A., Cai, Y., Märcher, A., Wall, A., Omer, M., Nielsen, J. S., Chudasama, V., Baker, J. R., Gothelf, K. V., Wengel, J., Kjems, J. & Howard, K. A. (2024). An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation. Bioconjugate Chemistry, 35(2), 214-222. https://doi.org/10.1021/acs.bioconjchem.3c00491

Westberg, M., Su, Y., Zou, X., Huang, P., Rustagi, A., Garhyan, J., Patel, P. B., Fernandez, D., Wu, Y., Hao, C., Lo, C. W., Karim, M., Ning, L., Beck, A., Saenkham-Huntsinger, P., Tat, V., Drelich, A., Peng, B. H., Einav, S. ... Lin, M. Z. (2024). An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations. Science Translational Medicine, 16(738), Article eadi0979. https://doi.org/10.1126/scitranslmed.adi0979

Kang, H., Niu, L., Zhang, F., Qing, C., Dong, M., Guan, L., Zhang, M. & Liu, Z. (2024). A Novel Piezoelectric Nonwoven Fabric for Recoverable High-Efficiency Filters. ACS Applied Materials and Interfaces, 16(40), 54566-54573. https://doi.org/10.1021/acsami.4c10922

Vallina, N. S., McRae, E. K. S., Geary, C. & Andersen, E. S. (2024). An RNA origami robot that traps and releases a fluorescent aptamer. Science Advances, 10(12), Article eadk1250. https://doi.org/10.1126/sciadv.adk1250

Cao, W., Xia, D., Zhou, L., Liu, Y., Wang, D., Liang, C. & Chen, M. (2024). Antibacterial and antioxidant wound dressings with pH responsive release properties accelerate chronic wound healing. Materials Today Physics, 40, Article 101316. https://doi.org/10.1016/j.mtphys.2023.101316

Otzen, D. E. (2024). Antibodies and α-synuclein: What to target against Parkinson's Disease? Biochimica et Biophysica Acta - Proteins and Proteomics, 1872(2), Article 140943. https://doi.org/10.1016/j.bbapap.2023.140943

Westensee, I. N., Thomsen, K. L., Mookerjee, R. P. & Stadler, B. M. (2024). Antioxidant Microgels Support Peroxide-Challenged Hepatic Cells. Advanced Biology, 8(4), Article e2300547. https://doi.org/10.1002/adbi.202300547

Westensee, I. N., Paffen, L., Pendlmayr, S., Andres, P. D. D., Ramos Docampo, M. A. & Stadler, B. M. (2024). Artificial Cells And HepG2 Cells in 3D Bioprinted Arrangements. Advanced Healthcare Materials, 13(12), Article 2303699. https://doi.org/10.1002/adhm.202303699

Søgaard, A. B., Skovbo, F., Tvilum, A., Hansson, R. F. & Zelikin, A. N. (2024). Artificial Internalizing Receptor Affords Fast, Potent, Specific Drug Delivery to the Chemically Engineered Cells. Advanced Functional Materials, 34(33), Article 2400048. https://doi.org/10.1002/adfm.202400048

Displaying results 231 to 240 out of 3464

24

Revised 03.03.2026

-

Kalinka Hansen