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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. (2019). Laser. Weekendavisen, Sektion 4 (Ideer), 10.

Thøgersen, J., Bak, E. N., Finster, K., Nørnberg, P., Jakobsen, H. J. & Knak Jensen, S. J. (2019). Light on windy nights on Mars: A study of saltation-mediated ionization of argon in a Mars-like atmosphere. Icarus, 332, 14-18. https://doi.org/10.1016/j.icarus.2019.06.025

Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, H., Nielsen, H. M., van Eden, W., Dong, M., Broere, F., Foged, C. & Zeng, X. (2019). Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model. European Journal of Pharmaceutics and Biopharmaceutics, 142, 38-48. https://doi.org/10.1016/j.ejpb.2019.06.009

Song, P., Yang, C., Thomsen, J. S., Dagnaes-Hansen, F., Jakobsen, M., Bruel, A., Deleuran, B. & Kjems, J. (2019). Lipidoid-siRNA Nanoparticle-Mediated IL-1 beta Gene Silencing for Systemic Arthritis Therapy in a Mouse Model. Molecular Therapy, 27(8), 1424-1435. https://doi.org/10.1016/j.ymthe.2019.05.002

Zhang, Z., Dong, MD., Yang, F. & Wang, Z. (2019). Liposome induced mechanical properties changes in cell membrane. In 2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) (pp. 202-205). Article 8947412 https://doi.org/10.1109/3M-NANO46308.2019.8947412

Erslev, T. (Ed.) & Eriksen, C. B. (2019). Livsvidenskabernes materialitet. Slagmark: tidsskrift for idéhistorie , 1-189.

Eriksen, C. B. & Erslev, T. (2019). Livsvidenskabernes materialitet: En introduktion. Slagmark: tidsskrift for idéhistorie , 78, 7-28.

Halkjær, S., Iversen, J., Kyhl, L., Chevallier, J., Andreatta, F., Yu, F., Stoot, A., Camilli, L., Bøggild, P., Hornekær, L. & Cassidy, A. M. (2019). Low-temperature synthesis of a graphene-based, corrosion-inhibiting coating on an industrial grade alloy. Corrosion Science, 152, 1-9. https://doi.org/10.1016/j.corsci.2019.01.029

Nielsen, K. H. (2019). Lsd. Weekendavisen, Sektion 4 (Ideer), 10.

Pedersen, J. N., Jiang, Z., Christiansen, G., Lee, J. C., Pedersen, J. S. & Otzen, D. E. (2019). Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures. Biochimica et Biophysica Acta - Proteins and Proteomics, 1867(5), 519-528. https://doi.org/10.1016/j.bbapap.2018.11.007

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Kalinka Hansen