Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Finster, K., Jensen, A.-M., Hansen, A., Lomstein, B. A., Nørberg, P. & Merrison, J. P. (2002). Description of a Mars-simulation facility. Paper presented at Graz, Austria, 16-19 September 2002.

Finster, K., Jensen, A. M., Lomstein, B. A., Nørnberg, P. & Merrison, J. P. (2002). Description of a Mars-simulation facility. Abstract from 2nd European Workshop on Exo/Astrobiology, Graz, Austria.

Ebbesen, M. (2002). Etisk vurdering indenfor lægevidenskab og bioteknologi. Bibliotek for Læger, 194, 232-259.

Ebbesen, M. (2002). Etisk vurdering indenfor lægevidenskab og bioteknologi. Bibliotek for Læger, 232-259.

Andersen, E. S. (2002). Evolutionsteori til debat. Delfinen, (96).

Nørberg, P., Finster, K., Folkmann, F., Gunnlaugsson, H. P., Hansen, A., Kinch, K., Lomstein, B. A. & Merrison, J. P. (2002). Facility at the Mars-simulation laboratory. Paper presented at Graz, Austria, 16-19 September 2002.

Hornekær, L. & Drewsen, M. (2002). Formation process of large ion Coulomb crystals in linear Paul traps. Physical Review A, 66.

Damgaard, C. K., Tange, T. Ø. & Kjems, J. (2002). hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure. RNA, 8.

Diekhöner, L., Hornekær, L., Mortensen, H., Jensen, E., Baurichter, A., Petrunin, V. V. & Luntz, A. C. (2002). Indirect evidence for strong nonadiabetic coupling in N₂ associative desorption from and dissociative adsorption on Ru(0001). Journal of Chemical Physics, 117(10), 5018.

Andersen, E. S. (2002). Intersubtype dimerization and recombination of HIV-1 genomic RNA. (Masters Thesis ed.) Aarhus University.

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