Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Hao, L., Du, Y., Wang, Z., Wu, Y., Xu, H., Dong, S., Liu, H., Liu, Y., Xue, Q., Han, Z., Yan, K. & Dong, M. (2020). Wafer-size growth of 2D layered SnSe films for UV-Visible-NIR photodetector arrays with high responsitivity. Nanoscale, 12(13), 7358-7365. https://doi.org/10.1039/d0nr00319k

Yang, T., Fruergaard, A. S., Winther, A. K., Zelikin, A. N. & Chandrawati, R. (2020). Zinc Oxide Particles Catalytically Generate Nitric Oxide from Endogenous and Exogenous Prodrugs. Small, 16(27), Article 1906744. https://doi.org/10.1002/smll.201906744

Nielsen, K. H. (2019). 1947-1952: UNESCO’s Division for Science & Its Popularization. Public Understanding of Science, 28(2), 246–251. https://doi.org/10.1177/0963662518787572

Hao, L., Wang, Z., Xu, H., Yan, K., Dong, S., Liu, H., Du, Y., Wu, Y., Liu, Y. & Dong, M. (2019). 2D SnSe/Si heterojunction for self-driven broadband photodetectors. 2D materials, 6(3), Article 034004. https://doi.org/10.1088/2053-1583/ab15f7

Nielsen, K. H. (2019). 5G. Weekendavisen, Sektion 4 (Ideer), 10.

Yang, Q., Wang, Z., Dong, L., Zhao, W., Jin, Y., Fang, L., Hu, B. & Dong, M. (2019). Activating MoS ₂ with Super-High Nitrogen-Doping Concentration as Efficient Catalyst for Hydrogen Evolution Reaction. Journal of Physical Chemistry C, 123(17), 10917-10925. https://doi.org/10.1021/acs.jpcc.9b00059

Nielsen, K. H. (2019). Aforisme. Weekendavisen, Sekton 4 (Ideer), 10.

Speed, M., Balding, D. J. & Hobolth, A. (2019). A general framework for moment-based analysis of genetic data. Journal of Mathematical Biology, 78(6), 1727-1769. https://doi.org/10.1007/s00285-018-01325-0

Nielsen, K. H. (2019). Akratisk. Weekendavisen, Sektion 4 (Ideer), 10.

Thomsen, R. P., Malle, M. G., Okholm, A. H., Krishnan, S., Bohr, S. S. R., Sørensen, R. S., Ries, O., Vogel, S., Simmel, F. C., Hatzakis, N. S. & Kjems, J. (2019). A large size-selective DNA nanopore with sensing applications. Nature Communications, 10(1), Article 5655. https://doi.org/10.1038/s41467-019-13284-1

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