Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Wang, Z. & Dong, M. (2020). Cutting Edge Materials of Two-Dimensional Platinum Diselenide. In L. Singh & D. M. Mahapatra (Eds.), Adapting 2D Nanomaterials for Advanced Applications (pp. 317-345). ACS (American Chemical Society). https://doi.org/10.1021/bk-2020-1353.ch013

Hjerrild, P., Tørring, T. & Poulsen, T. B. (2020). Dehydration reactions in polyfunctional natural products. Natural Product Reports, 37(8), 1043-1064. https://doi.org/10.1039/d0np00009d

Hetland, P., Kasperowski, D. & Nielsen, K. H. (2020). Denmark, Norway, and Sweden: Share, make useful and critically discuss science communication. In T. Gascoigne, B. Schiele, J. Leach, M. Riedlinger, B. V. Lewenstein, L. Massarani & P. Broks (Eds.), Communicating science: a global perspective (pp. 253-278). ANU Press. https://doi.org/10.22459/CS.2020

Finster, K. (2020). Derfor kan bakterier fra chilensk bjergsø bruges som kig til livets børneværelse. Ingeniøren, Sektion 1, 14-15.

Adão, R., Cruz, P. F., Vaz, D. C., Fonseca, F., Pedersen, J. N., Ferreira-da-Silva, F., Brito, R. M. M., Ramos, C. H. I., Otzen, D., Keller, S. & Bastos, M. (2020). DIBMA nanodiscs keep α-synuclein folded. Biochimica et biophysica acta - Biomembranes, 1862(9), Article 183314. https://doi.org/10.1016/j.bbamem.2020.183314

Ma, R., Haastrup, M. J., Wang, Z., Liu, Y., Ye, H., Dong, M., Lauritsen, J. V. & Sutherland, D. S. (2020). Direct Integration of Few-Layer MoS₂ at Plasmonic Au Nanostructure by Substrate-Diffusion Delivered Mo. Advanced Materials Interfaces, 7(8), Article 1902093. https://doi.org/10.1002/admi.201902093

Jiang, A., Zhang, W., Wang, Z., Nidamanuri, N. P., Li, Q., Zeng, X. C. & Dong, M. (2020). Direct synthesis of bifunctional nanorods from a Co-adenine-MoO₃ hybrid for overall water splitting. Materials Chemistry Frontiers, 4(2), 546-554. https://doi.org/10.1039/c9qm00626e

Qian, X., Gargalo, C. L., Gernaey, K. V. & Städler, B. (2020). Distinguishing Commercial Beers Using a Solution-Based Sensor Array Derived from Nanoscale Polydiacetylene Vesicles. ACS Applied Nano Materials, 3(4), 3439−3448. https://doi.org/10.1021/acsanm.0c00187

Nielsen, K. H. (2020). Død eller levende. Weekendavisen, (Sektion 4 (Ideer)), 5.

Zhang, Y., Li, Q., Dong, M. & Han, X. (2020). Effect of cholesterol on the fluidity of supported lipid bilayers. Colloids and Surfaces B: Biointerfaces, 196(December), Article 111353. https://doi.org/10.1016/j.colsurfb.2020.111353

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