Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

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Sljivancanin, Z., Rauls, E., Hornekær, L., Xu, W., Besenbacher, F. & Hammer, B. (2009). Extended atomic hydrogen dimer configurations on the graphite (0001) surface. Journal of Chemical Physics, 131, 084706.

Basaiawmoit, R. V., Oliveira, C. L. P. D., Runager, K., Kristensen, T., Enghild, J. J., Pedersen, J. S. & Otzen, D. (2009). First Low Resolution Structural Evidence of Full-length TGFBIp and Its Implications in TGFBI-linked Corneal Dystrophy. Abstract from ARVO 2009 Annual Meeting, nr. 2009, Fort Lauderdale, USA, 3. maj - 7. maj 2009, Investigative Ophthalmology & Visual Science. 2009. E-Abstract 4311. Association for Research in Vision and Ophthalmology..

Nielsen, M. M. & Andersen, E. S. (2009). Forskere som nano-arkitekter. Aktuel Naturvidenskab, (3), 30-35.

Andersen, L. D., Ostenfeld, M. S., Bramsen, J. B., Silahtaroglu, A., Lamy, P., Ramanathan, R., Fristrup, N., Jensen, J. L., Andersen, C. L., Zieger, K., Kauppinen, S., Ulhøi, B. P., Kjems, J., Borre, M. & Ørntoft, T. F. (2009). Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Research, 69(11), 4851-60. https://doi.org/10.1158/0008-5472.CAN-08-4043

Finster, K. (2009). Gode chancer for liv på Mars. Aktuel Naturvidenskab, 4, 5-7.

Andersen, M. G. & Kjems, J. (2009). Guld får medicinen frem i kroppen. Aktuellt i Politiken.

Andersen, K. & Otzen, D. (2009). How chain length and charge affect surfactant denaturation of ACBP. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 113, 13942-13952.

Schiølin, K. H. (2009). Hvad blev der af prisopgaven? CAMPUS, (18), 14-14. http://www.au.dk/univers/arkiv/2009/artikler/nr18/debat2/

Malsch, I. & Nielsen, K. H. (2009). Individual and collective responsibility for nanotechnology.

Li, Y., Dong, M., Otzen, D., Yao, Y., Liu, B., Besenbacher, F. & Mamdouh, W. (2009). Influence of tunable external stimuli on the self-assembly of guanosine supramolecular nanostructures studied by atomic force microscope. Langmuir, 25.

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