Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

Sort by: Date | Author | Title

Hirsch, C. (2015). A Harris-Kesten theorem for confetti percolation. Random Structures Algorithms, 47(2), 361-385.

Howard, K. A. (2015). Albumin: The next-generation delivery technology. Therapeutic Delivery, 6(3), 265-268. https://doi.org/10.4155/tde.14.124

Košmrlj, A., Cordsen, P., Kyrsting, A., Otzen, D., Oddershede, L. B. & Jensen, M. H. (2015). A monomer-trimer model supports intermittent glucagon fibril growth. Scientific Reports, 5, 1-6. Article 9005. https://doi.org/10.1038/srep09005

Wang, X., Weber, J. K., Liu, L., Dong, M., Zhou, R. & Li, J. (2015). A novel form of β-strand assembly observed in Aβ_33-42 adsorbed onto graphene. Nanoscale, 7(37), 15341-15348. https://doi.org/10.1039/c5nr00555h

Ebbesen, M., Sundby, A., Pedersen, F. S. & Andersen, S. (2015). A Philosophical Analysis of Informed Consent for Whole Genome Sequencing in Biobank Research by use of Beauchamp and Childress' Four Principles of Biomedical Ethics. Journal of Clinical Research and Bioethics, 6(244). https://doi.org/10.4172/2155-9627.1000244

Xu, R., Taskin, M. B., Dagnæs-Hansen, F., Meyer, T., Bach, L. W., Axelsen, S. M., Besenbacher, F. & Chen, M. (2015). Application of a Novel 3D Biofunctional Scaffold for hiPS-MSC Fibrogenesis. Abstract from 2015 4th TERMIS World Congress , Boston, United States. http://online.liebertpub.com/toc/tea/21/S1

Aller, P., Sanchez-Weatherby, J., Foadi, J., Winter, G., Lobley, C. M. C., Axford, D., Ashton, A. W., Bellini, D., Brandao-Neto, J., Culurgioni, S., Douangamath, A., Duman, R., Evans, G., Fisher, S., Flaig, R., Hall, D. R., Lukacik, P., Mazzorana, M., McAuley, K. E. ... Walsh, M. A. (2015). Application of in situ diffraction in high-throughput structure determination platforms. Methods in molecular biology (Clifton, N.J.), 1261, 233-53. https://doi.org/10.1007/978-1-4939-2230-7_13

Liu, L., Li, Y., Xia, D., Bortolini, C., Zhang, S., Yang, Y., Pedersen, J. S., Wang, C., Besenbacher, F. & Dong, M. (2015). A self-assembled nanopatch with peptide-organic multilayers and mechanical properties. Nanoscale, 7(6), 2250-2254. https://doi.org/10.1039/c4nr03797a

Hirsch, C., Neuhäuser, D., Gloaguen, C. & Schmidt, V. (2015). Asymptotic properties of Euclidean shortest-path trees in random geometric graphs. Statistics probability letters, 107, 122-130.

Sun, M., Wang, M., Chen, M., Dagnaes-Hansen, F., Le, D. Q. S., Baatrup, A., Horsman, M. R., Kjems, J. & Bünger, C. (2015). A tissue-engineered therapeutic device inhibits tumor growth in vitro and in vivo. Acta Biomaterialia, 18, 21-29. https://doi.org/10.1016/j.actbio.2015.02.004

Displaying results 1881 to 1890 out of 3467

189