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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Vu-Quang, H., Vinding, M. S., Nielsen, T., Ullisch, M. G., Nielsen, N. C., Nguyen, D. T. & Kjems, J. (2019). Pluronic F127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging. Polymers, 11(4), Article 743. https://doi.org/10.3390/polym11040743

Gal, N., Charwat, V., Städler, B. & Reimhult, E. (2019). Poly(ethylene glycol) grafting of nanoparticles prevents uptake by cells and transport through cell barrier layers regardless of shear flow andpParticle size. ACS Biomaterials Science and Engineering, 5(9), 4355-4365. https://doi.org/10.1021/acsbiomaterials.9b00611

Kang, S., He, M., Chen, M., Wang, Z., Sun, Z., Dang, H., Chang, X., Dong, M., Liu, P. & Cui, L. (2019). Polymeric structure optimization of g-C₃N₄ by using confined argon-assisted highly-ionized ammonia plasma for improved photocatalytic activity. Journal of Colloid and Interface Science, 556, 214-223. https://doi.org/10.1016/j.jcis.2019.08.040

De Vrieze, J., Louage, B., Deswarte, K., Zhong, Z., De Coen, R., Van Herck, S., Nuhn, L., Kaas Frich, C., Zelikin, A. N., Lienenklaus, S., Sanders, N. N., Lambrecht, B. N., David, S. A. & De Geest, B. G. (2019). Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. Angewandte Chemie - International Edition, 58(43), 15390-15395. https://doi.org/10.1002/anie.201905687

Nielsen, S. B. & Otzen, D. E. (2019). Quartz Crystal Microbalances as Tools for Probing Protein-Membrane Interactions. In J. H. Kleinschmidt (Ed.), Methods in Molecular Biology: Methods and Protocols (Vol. 2003, pp. 31-52). Springer. https://doi.org/10.1007/978-1-4939-9512-7_2

Westberg, M., Etzerodt, M. & Ogilby, P. R. (2019). Rational Design of Genetically Encoded Singlet Oxygen Photosensitizing Proteins. Current Opinion in Structural Biology, 57(August), 56-62. https://doi.org/10.1016/j.sbi.2019.01.025

Zhu, X., Ding, R., Wang, Z., Wang, Y., Guo, X., Song, Z., Wang, Z. & Dong, M. (2019). Recent advances in synthesis and biosensors of two-dimensional MoS₂. Nanotechnology, 30(50), Article 502004. https://doi.org/10.1088/1361-6528/ab42fe

Qian, X. & Städler, B. (2019). Recent Developments in Polydiacetylene-Based Sensors. Chemistry of Materials, 31(4), 1196-1222. https://doi.org/10.1021/acs.chemmater.8b05185

Christensen, L. F. B., Jensen, K. F., Nielsen, J., Vad, B. S., Christiansen, G. & Otzen, D. E. (2019). Reducing the Amyloidogenicity of Functional Amyloid Protein FapC Increases Its Ability To Inhibit α-Synuclein Fibrillation. ACS Omega, 4(2), 4029-4039. https://doi.org/10.1021/acsomega.8b03590

Bortolini, C., Kartanas, T., Copic, D., Condado Morales, I., Zhang, Y., Challa, P. K., Peter, Q., Jávorfi, T., Hussain, R., Dong, M., Siligardi, G., Knowles, T. P. J. & Charmet, J. (2019). Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism. Lab on a Chip, 19(1), 50-58. https://doi.org/10.1039/c8lc00757h

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Kalinka Hansen