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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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González-García, M., Morales-Vicente, F., Pico, E. D., Garay, H., Rivera, D. G., Grieshober, M., Olari, L. R., Groß, R., Conzelmann, C., Krüger, F., Zech, F., Bozzo, C. P., Müller, J. A., Zelikin, A., Raber, H., Kubiczek, D., Rosenau, F., Münch, J., Stenger, S. ... Otero-Gonzalez, A. J. (2021). Antimicrobial activity of cyclic-monomeric and dimeric derivatives of the snail-derived peptide cm-p5 against viral and multidrug-resistant bacterial strains. Biomolecules, 11(5), Article 745. https://doi.org/10.3390/biom11050745

Yu, Z., Centola, M., Valero, J., Matthies, M., Šulc, P. & Famulok, M. (2021). A Self-Regulating DNA Rotaxane Linear Actuator Driven by Chemical Energy. Journal of the American Chemical Society, 143(33), 13292-13298. https://doi.org/10.1021/jacs.1c06226

Choong, F. X., Huzell, S., Rosenberg, M., Eckert, J. A., Nagaraj, M., Zhang, T., Melican, K., Otzen, D. E. & Richter-Dahlfors, A. (2021). A semi high-throughput method for real-time monitoring of curli producing Salmonella biofilms on air-solid interfaces. Biofilm, 3, Article 100060. https://doi.org/10.1016/j.bioflm.2021.100060

Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D., Pedersen, F. S., Birkedal, V., Wagner, R., Paludan, S. R. & Kjems, J. (2021). A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Proceedings of the National Academy of Sciences (PNAS), 118(50), Article e2112942118. https://doi.org/10.1073/pnas.2112942118

Zhang, Y., Zhang, D., Wang, Y., Liu, Q., Li, Q. & Dong, MD. (2021). Atomic-Scale Friction of Black and Violet Phosphorus Crystals: Implications for Phosphorus-Based Devices and Lubricants. ACS Applied Nano Materials, 4(9), 9932-9937. https://doi.org/10.1021/acsanm.1c02593

Nielsen, K. H. (2021). Atomic Urbanism under Greenland’s Ice Cap: Camp Century and Cold War Architectural Imagination. In R. Brook, M. Dodge & J. Hogg (Eds.), Cold War Cities: Politics, Culture and Atomic Urbanism, 1945-1965 (pp. 182-199). Routledge. https://doi.org/10.4324/9780203701478

Ahmed, S. Z., Hjorth, A., Rafner, J. F., Weidner, C. A., Kragh, G., Jensen, J. H. M., Bobroff, J., Nielsen, K. H. & Sherson, J. F. (2021). A training programme for early-stage researchers that focuses on developing personal science outreach portfolios. Science Communication https://doi.org/10.48550/arXiv.2103.03109

Otzen, D. E., Morshedi, D., Mohammad-Beigi, H. & Aliakbari, F. (2021). A Triple Role for a Bilayer: Using Nanoliposomes to Cross and Protect Cellular Membranes. Journal of Membrane Biology, 254(1), 29-39. https://doi.org/10.1007/s00232-020-00159-6

Wang, Z., Cui, Y., Feng, Y., Guan, L., Dong, M., Liu, Z. & Liu, L. (2021). A versatile Silk Fibroin based filtration membrane with enhanced mechanical property, disinfection and biodegradability. Chemical Engineering Journal, 426, Article 131947. https://doi.org/10.1016/j.cej.2021.131947

Mandrup, O. A. & Howard, K. (2021). Bioengineered solutions to improve cancer immunotherapies. Therapeutic Delivery, 12(5), 339-341 . https://doi.org/10.4155/tde-2021-0019

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Kalinka Hansen