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Recent research news on Artificial Biology

Single Protein-Mediated Vesicle Division

Steering group member of AUNAB, Prof. Brigitte Städler, has published a collaborative study in Advanced Materials on the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles.

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Qian, X., Westensee, I. N., Fernandes, C. C. & Städler, B. (2021). Enzyme Mimic Facilitated Artificial Cell to Mammalian Cell Signal Transfer. Angewandte Chemie - International Edition, 60(34), 18704-18711. https://doi.org/10.1002/anie.202104904
Brito, L. F., Irla, M., Nærdal, I., Le, S. B., Delépine, B., Heux, S. & Brautaset, T. (2021). Evaluation of Heterologous Biosynthetic Pathways for Methanol-Based 5-Aminovalerate Production by Thermophilic Bacillus methanolicus. Frontiers in Bioengineering and Biotechnology, 9, Article 686319. https://doi.org/10.3389/fbioe.2021.686319
De Dios Andres, P., Westensee, I. N., Brodszkij, E., Ramos-Docampo, M. A., Gal, N. & Städler, B. (2021). Evaluation of Hybrid Vesicles in an Intestinal Cell Model Based on Structured Paper Chips. Biomacromolecules, 22(9), 3860-3872. https://doi.org/10.1021/acs.biomac.1c00686
Borup, K. & Andersen, L. N. (2021). Even your Teacher Needs Guidance: Ground-Truth Targets Dampen Regularization Imposed by Self-Distillation. In MA. Ranzato, A. Beygelzimer, Y. Dauphin, P. S. Liang & J. Wortman Vaughan (Eds.), Advances in Neural Information Processing Systems 34 - 35th Conference on Neural Information Processing Systems, NeurIPS 2021 (pp. 5316-5327). Neural Information Processing Systems Foundation. https://proceedings.neurips.cc/paper_files/paper/2021/file/2adcefe38fbcd3dcd45908fbab1bf628-Paper.pdf
Borup, K. & Andersen, L. N. (2021). Even your Teacher Needs Guidance: Ground-Truth Targets Dampen Regularization Imposed by Self-Distillation. Paper presented at Conference on Neural Information Processing Systems 2021. https://proceedings.neurips.cc/paper/2021/file/2adcefe38fbcd3dcd45908fbab1bf628-Paper.pdf
Lin, S., Liu, H., Svenningsen, E. B., Wollesen, M., Jacobsen, K. M., Andersen, F. D., Moyano-Villameriel, J., Pedersen, C. N., Nørby, P., Tørring, T. & Poulsen, T. B. (2021). Expanding the antibacterial selectivity of polyether ionophore antibiotics through diversity-focused semisynthesis. Nature Chemistry, 13(1), 47-55. https://doi.org/10.1038/s41557-020-00601-1
Petermeier, P., Fortuna, C., M. Hübschmann, K., Nahuel Bidart Costoya, G., Tørring, T., Teze, D., Welner, D. H. & Kara, S. (2021). Exploring the in Vitro Operating Window of Glycosyltransferase PtUGT1 from Polygonum tinctorium for a Biocatalytic Route to Indigo Dye. ACS Sustainable Chemistry & Engineering, 9(25), 8497-8506. https://doi.org/10.1021/acssuschemeng.1c01536
Rudnik-Jansen, I. & Howard, K. (2021). FcRn expression in cancer: Mechanistic basis and therapeutic opportunities. Journal of Controlled Release, 337, 248-257. https://doi.org/10.1016/j.jconrel.2021.07.007
Langmüller, A. M., Dolezal, M. & Schlötterer, C. (2021). Fine Mapping without Phenotyping: Identification of Selection Targets in Secondary Evolve and Resequence Experiments. Genome Biology and Evolution, 13(8), Article evab154. https://doi.org/10.1093/gbe/evab154
Jeng, S. S., Trachman, R. J., Weissenboek, F., Troung, L., Link, K., Jepsen, M. B., Knutson, J., Andersen, E., Ferré-D'Amaré, A. R. & Unrau, P. J. (2021). Fluorogenic aptamers resolve the flexibility of RNA junctions using orientation-dependent FRET. RNA, 27(4), 433-444. https://doi.org/10.1261/rna.078220.120

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Kalinka Hansen