Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Otzen, D. & Riek, R. (2019). Functional Amyloids. Cold Spring Harbor Perspectives in Biology, 11(12), Article a033860. https://doi.org/10.1101/cshperspect.a033860

Krissanaprasit, A., Key, C., Fergione, M., Froehlich, K., Pontula, S., Hart, M., Carriel, P., Kjems, J., Andersen, E. S. & LaBean, T. H. (2019). Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant. Advanced Materials, 31(21), Article 1808262. https://doi.org/10.1002/adma.201808262

Nielsen, K. H. (2019). Gold fever in Greenland: Sociotechnical imaginaries of gold resources, 1988–2013. 73. Abstract from 10th Biennial conference of the European Society for Environmental History, Tallinn, Estonia.

Zhang, C., Tu, R., Liu, L., Li, J., Dong, M., Wang, Z., Shi, J., Li, H., Ohmori, H., Zhang, S., Zhang, L. & Goto, T. (2019). Growth and carrier transport performance of single-crystalline monolayer graphene over electrodeposited copper film on quartz glass. Ceramics International, 45(18, Part A), 24254-24259. https://doi.org/10.1016/j.ceramint.2019.08.137

Zhang, C., Tu, R., Dong, M., Li, J., Yang, M., Li, Q., Shi, J., Li, H., Ohmori, H., Zhang, S., Zhang, L. & Goto, T. (2019). Growth of umbrella-like millimeter-scale single-crystalline graphene on liquid copper. Carbon, 150, 356-362. https://doi.org/10.1016/j.carbon.2019.05.013

Moldovan, L.-I., Hansen, T. B., Venø, M. T., Okholm, T. L. H., Andersen, T. L., Hager, H., Iversen, L., Kjems, J., Johansen, C. & Kristensen, L. S. (2019). High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome. BMC Medical Genomics, 12(1), Article 174. https://doi.org/10.1186/s12920-019-0616-2

Nielsen, K. H. (2019). Holodomor. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2019). Homoseksuel. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2019). Hvordan styrker vi borgernes rolle i citizen science?. 19. Abstract from Citizen Science Symposium, Odense, Denmark. https://citizenscienceportalen.files.wordpress.com/2019/10/symposiumbog-final.pdf

Zhang, Y., Gal, N., Itel, F., Westensee, I. N., Brodszkij, E., Mayer, D., Stenger, S., Castellote-Borrell, M., Boesen, T., Tabaei, S. R., Hook, F. & Stadler, B. (2019). Hybrid vesicles as intracellular reactive oxygen species and nitric oxide generators. Nanoscale, 11(24), 11530-11541. https://doi.org/10.1039/c9nr02584g

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