Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Wittenborn, T., Nygaard, J. V., Horsman, M. R., Vorup-Jensen, T., Kjems, J., Thim, T., Nielsen, T., Larsen, E. K. U. & Falk, E. (2009). A Novel in Vivo Angiogenesis Mouse Model. Arteriosclerosis, Thrombosis, and Vascular Biology, (7).

Mailund, T., Nielsen, J. & Pedersen, C. S. (2009). A Quadratic Time Algorithm for Computing the Quartet Distance between Two General Trees. In Proceedings of IJCBS 2009 (pp. 565-568). IEEE Computer Society Press. https://doi.org/10.1109/IJCBS.2009.42

Balog, R., Jørgensen, B., Wells, J., Lægsgaard, E., Hofmann, P., Besenbacher, F. & Hornekær, L. (2009). Atomic hydrogen adsorbate structures on graphene. Journal of the American Chemical Society, 131(25), 8744. https://doi.org/10.1021/ja902714h

Kristensen, T. G., Nielsen, J. & Pedersen, C. N. S. (2009). A tree based method for the rapid screening of chemical fingerprints. Lecture Notes in Computer Science, 5724, 194-205. https://doi.org/10.1007/978-3-642-04241-6_17

Liboriussen, P., Pedersen, B. P., Ifrim, G., Nissen, P. & Pedersen, C. S. (2009). Automatic classification of P-Type ATPases using SLR. Poster session presented at 17th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 8th European Conference on Computational Biology (ECCB), Stockholm, Sweden.

Huynh, T. H. V., Mantel, M., Mikkelsen, K., Lindhardt, A. T., Nielsen, N. C., Otzen, D. & Skrydstrup, T. (2009). A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis. Organic Letters, 11, 999-1002.

Ebbesen, M. (2009). Bioethics in theory and practice.

Yde, J. C., Finster, K., Hodson, A. J., Knudsen, N. T., Bárcena, T. G., Bartholomew, I., Lawson, E., Nienow, P. W., Tranter, M. & Wadham, J. L. (2009). Biogeochemical processes in Greenlandic glacial waters. Poster session presented at 19th International Symposium on Environmental Biogeochemistry, Hamburg, Germany.

Finster, K. & Yde, J. C. (2009). Biogeochemical studies of glacial ecosystems in Greenland. Poster session presented at Beyond Kyoto: Addressing the Challenges of Climate Change - Science meets Industry, Policy and the Public, Århus, Denmark.

Søbjerg, L. S., Gauthier, D., Lindhardt, A. T., Bunge, M., Finster, K., Meyer, R. L. & Skrydstrup, T. (2009). Bio-supported palladium nanoparticles as a catalyst for Suzuki-Miyaura and Mizoroki-Heck reactions. Green Chemistry, 11, 2041-2046. https://doi.org/10.1039/b918351p

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