Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, K. H. (2020). Gode mutationer. Weekendavisen, (Sektion 4 (Ideer)), 5.

Kastorp, C. F. P., Duncan, D. A., Scheffler, M., Thrower, J. D., Jørgensen, A. L., Hussain, H., Lee, T. L., Hornekær, L. & Balog, R. (2020). Growth and electronic properties of bi- And trilayer graphene on Ir(111). Nanoscale, 12(38), 19776-19786. https://doi.org/10.1039/d0nr04788k

Zhang, C., Wang, Z., Tu, R., Dong, M., Li, J., Yang, M., Li, Q., Shi, J., Li, H., Ohmori, H., Zhang, S., Zhang, L. & Goto, T. (2020). Growth of self-aligned single-crystal vanadium carbide nanosheets with a controllable thickness on a unique staked metal substrate. Applied Surface Science, 499, Article 143998. https://doi.org/10.1016/j.apsusc.2019.143998

Simonsen, F. D. S., Jensen, P. A., Skov, A. W., Jaganathan, R., Thrower, J. & Hornekær, L. (2020). H2 catalysis through superhydrogenation of interstellar polycyclic aromatic hydrocarbons. In F. Salama & H. Linnartz (Eds.), Laboratory Astrophysics: From Observations to Interpretation (Vol. 15, pp. 264-266). Cambridge University Press. https://doi.org/10.1017/S1743921320000034

Ke, P. C., Zhou, R., Serpell, L. C., Riek, R., Knowles, T. P. J., Lashuel, H. A., Gazit, E., Hamley, I. W., Davis, T. P., Fändrich, M., Otzen, D. E., Chapman, M. R., Dobson, C. M., Eisenberg, D. S. & Mezzenga, R. (2020). Half a century of amyloids: past, present and future. Chemical Society Reviews, 49(15), 5473-5509. https://doi.org/10.1039/c9cs00199a

Fang, X., Wang, Z., Kang, S., Zhao, L., Jiang, Z. & Dong, M. (2020). Hexagonal CoSe₂ nanosheets stabilized by nitrogen-doped reduced graphene oxide for efficient hydrogen evolution reaction. International Journal of Hydrogen Energy, 45(3), 1738-1747. https://doi.org/10.1016/j.ijhydene.2019.11.059

Nielsen, K. H. (2020). Hvem tilhører Den Gamle? Weekendavisen, (Sektion 4 (Ideer)), 5.

Feng, Q., Hong, Y., Pradeep Nidamanuri, N., Yang, C., Li, Q. & Dong, M. (2020). Identification and Nanomechanical Characterization of the HIV Tat-Amyloid β Peptide Multifibrillar Structures. Chemistry - A European Journal, 26(43), 9449-9453. https://doi.org/10.1002/chem.201905715

Li, Y., Nidamanuri, N. P., Jiang, A., Wang, Z., Li, Q. & Dong, M. (2020). In situ construction of tandem nitrogen-doped MoP nanocrystals for high-efficient electrocatalytic hydrogen evolution. Electrochimica Acta, 342, Article 136059. https://doi.org/10.1016/j.electacta.2020.136059

Omer, M., Andersen, V. L., Nielsen, J. S., Wengel, J. & Kjems, J. (2020). Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds. Molecular Therapy - Nucleic Acids, 22, 994-1003. https://doi.org/10.1016/j.omtn.2020.10.013

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