Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

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Basse-O'Connor, A., Podolskij, M. & Thäle, C. (2020). A Berry-Esseén theorem for partial sums of functionals of heavy-tailed moving averages. Electronic Journal of Probability, 25, 1-31. Article 31. https://doi.org/10.1214/20-EJP435

Su, Y., Taskin, M. B., Dong, MD., Han, X., Besenbacher, F. & Chen, M. (2020). A biocompatible artificial tendril with a spontaneous 3D Janus multi-helix-perversion configuration. Materials Chemistry Frontiers, 4(7), 2149-2156. https://doi.org/10.1039/D0QM00125B

Javed, I., Zhang, Z., Adamcik, J., Andrikopoulos, N., Li, Y., Otzen, D. E., Lin, S., Mezzenga, R., Davis, T. P., Ding, F. & Ke, P. C. (2020). Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC. Advanced Science, 7(18), Article 2001299. https://doi.org/10.1002/advs.202001299

Stoll, L., Rodríguez-Trejo, A., Guay, C., Brozzi, F., Bayazit, M. B., Gattesco, S., Menoud, V., Sobel, J., Marques, A. C., Venø, M. T., Esguerra, J. L. S., Barghouth, M., Suleiman, M., Marselli, L., Kjems, J., Eliasson, L., Renström, E., Bouzakri, K., Pinget, M. ... Regazzi, R. (2020). A circular RNA generated from an intron of the insulin gene controls insulin secretion. Nature Communications, 11, Article 5611. https://doi.org/10.1038/s41467-020-19381-w

Pedersen, J. N., Lyngsø, J., Zinn, T., Otzen, D. & Pedersen, J. S. (2020). A complete picture of protein unfolding and refolding in surfactants. Chemical Science, 11(3), 699-712. https://doi.org/10.1039/C9SC04831F

Das Mahapatra, K., Pasquali, L., Søndergaard, J. N., Lapins, J., Nemeth, I. B., Baltás, E., Kemény, L., Homey, B., Moldovan, L. I., Kjems, J., Kutter, C., Sonkoly, E., Kristensen, L. S. & Pivarcsi, A. (2020). A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma. Scientific Reports, 10, Article 3637. https://doi.org/10.1038/s41598-020-59660-6

Su, Y., Zhang, Z., Wan, Y., Zhang, Y., Wang, Z., Klausen, L. H., Huang, P., Dong, MD., Han, X., Cui, B. & Chen, M. (2020). A hierarchically ordered compacted coil scaffold for tissue regeneration. NPG Asia Materials, 12(1), Article 55. https://doi.org/10.1038/s41427-020-0234-7

Zhu, T., Liang, Y., Zhang, C., Wang, Z., Dong, M., Wang, C., Yang, M., Goto, T., Tu, R. & Zhang, S. (2020). A high-throughput synthesis of large-sized single-crystal hexagonal boron nitride on a Cu-Ni gradient enclosure. RSC Advances, 10(27), 16088-16093. https://doi.org/10.1039/d0ra00734j

Pilati, D. & Howard, K. (2020). Albumin-based drug designs for pharmacokinetic modulation. Expert Opinion on Drug Metabolism & Toxicology, 16(9), 783-795. https://doi.org/10.1080/17425255.2020.1801633

Cai, Y., Lou, C., Wengel, J. & Howard, K. A. (2020). Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics. In T. Yokota & R. Maruyama (Eds.), Gapmers : Methods and Protocols (pp. 163-174). Humana Press. https://doi.org/10.1007/978-1-0716-0771-8_12

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