Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Basse Eriksen, C. (2022). Magnifying the first points of life: Harvey and Descartes on generation and scale. History of Science, 60(4), 524-545. https://doi.org/10.1177/00732753211033476

Savchak, O. K., Wang, N., Ramos-Docampo, M. A., de Dios Andres, P., Sebastião, A. M., Ribeiro, F. F., Armada-Moreira, A., Städler, B. & Vaz, S. H. (2022). Manganese dioxide nanosheet-containing reactors as antioxidant support for neuroblastoma cells. Journal of Materials Chemistry B, 10(24), 4672-4683. https://doi.org/10.1039/d2tb00393g

Nielsen, K. H. (2022). Mekaniske tyrkere. Weekendavisen, Sektion 4 (Ideer), 5.

Brodszkij, E., Westensee, I. N., Holleufer, S. F., Ade, C., Andres, P. D. D., Pedersen, J. S. & Städler, B. (2022). Membrane composition of polymer-lipid hybrid vesicles. Applied Materials Today, 29, Article 101549. https://doi.org/10.1016/j.apmt.2022.101549

Nielsen, K. H. (2022). Mendels ærteplanter. Weekendavisen, Sektion 4 (Ideer), 5.

Nørnberg, P., Finster, K., Thøgersen, J., Golbek, T. W., Weidner, T., Hassenkam, T., Goetz, W., Oehlke, M. & Knak Jensen, S. J. (2022). Methane as a reddish coating agent. Icarus, 382, Article 115023. https://doi.org/10.1016/j.icarus.2022.115023

Kolchev, I., Marshall, I. P. G., Jones, E., Yde, J. C., Nørnberg, P., Rivera, A. M., Hodson, A. J., Bak, E. N. & Finster, K. (2022). Microbial iron reduction and greenhouse gas production in response to organic matter amendment and temperature increase of periglacial sediments, Bolterdalen, Svalbard. Arctic, Antarctic, and Alpine Research, 54(1), 314-334. https://doi.org/10.1080/15230430.2022.2097757

Ade, C., Marcelino, T. F., Dulchavsky, M., Wu, K., Bardwell, J. C. A. & Städler, B. (2022). Microreactor equipped with naturally acid-resistant histidine ammonia lyase from an extremophile. Materials Advances, 3(8), 3649-3662. https://doi.org/10.1039/d2ma00051b

Eriksen, C. B. (2022). Microscopy in Early Modern Natural Philosophy. In D. Jalobeanu & C. T. Wolfe (Eds.), Encyclopedia of Early Modern Philosophy and the Sciences (pp. 1332-1343). Springer. https://doi.org/10.1007/978-3-319-31069-5_151

Raza, U., Oh, S., Tabassian, R., Mahato, M., Hiep Nguyen, V. & Oh, I.-K. (2022). Micro-Structured Porous Electrolytes for Highly Responsive Ionic Soft Actuators. Sensors and Actuators B: Chemical, 352(Part 1), Article 131006. https://doi.org/10.1016/j.snb.2021.131006

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