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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nielsen, J., Kristensen, A. K., Mailund, T. & Pedersen, C. N. S. (2011). A sub-cubic time algorithm for computing the quartet distance between two general trees. Algorithms for Molecular Biology, 6(15). https://doi.org/10.1186/1748-7188-6-15

Du, X., Wang, L., Wang, Y., Andreasen, M., Zhan, D., Feng, Y., Li, M., Zhao, M., Otzen, D., Xue, D., Yang, Y. & Liu, R. (2011). Aβ_1-16Can Aggregate and induce the Production of Reactive Oxygen Species, Nitric Oxide, and Inflammatory Cytokines. Journal of Alzheimer's Disease, 27(2), 401-413. https://doi.org/10.3233/JAD-2011-110476

Li, Y., Liu, L., Subramani, R., Pan, Y., Liu, B., Yang, Y., Wang, C., Mamdouh, W., Besenbacher, F. & Dong, M. (2011). Building layer-by-layer 3D supramolecular nanostructures at the terephthalic acid/stearic acid interface. Chemical Communications, 47(32), 9155-9157. https://doi.org/10.1039/c1cc11443c

Yao, Y., Chen, D., Zhang, S., Li, Y., Tu, P., Liu, B. & Dong, M. (2011). Building the first hydration shell of deprotonated glycine by the MCMM and ab initio methods. Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 115(19), 6213-21. https://doi.org/10.1021/jp1117097

Nygaard, J. V., Uyar, T., Chen, M., Cloetens, P., Kingshott, P. & Besenbacher, F. (2011). Characterisation of internal morphologies in electrospun fibers by X-ray tomographic microscopy. Nanoscale, 3. https://doi.org/10.1039/c1nr10304k

Bramsen, J. B. & Kjems, J. (2011). Chemical modification of small interfering RNA. Methods in Molecular Biology, 721(1), 77-103. https://doi.org/10.1007/978-1-61779-037-9_5

Nielsen, K. H. (2011). City under the Ice: The Closed World of Camp Century. Abstract from HSS Annual Meeting, Cleveland, OH, United States. http://www.hssonline.org/Meeting/2011HSSMeeting/Program%20Abstracts.pdf

Locke, D. P., Hillier, L. W., Warren, W. C., Yang, S.-P., Wang, Z., Chinwalla, A. T., Minx, P., Mitreva, M., Cook, L., Delehaunty, K. D., Fronick, C., Schmidt, H., Fulton, L. A., Fulton, R. S., Nelson, J. O., Magrini, V., Pohl, C., Graves, T. A., Markovic, C. ... de Jong, P. J. (2011). Comparative and demographic analysis of orang-utan genomes. Nature, 469, 529-533. https://doi.org/10.1038/nature09687

Tataru, P. C. & Hobolth, A. (2011). Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains. BMC Bioinformatics, 12(1), 465. https://doi.org/10.1186/1471-2105-12-465

Jepsen, M. DE., Beerens, N., Besenbacher, F., Kjems, J. & Birkedal, V. (2011). Conformational changes of HIV-1 RNA upon tRNA primer annealing studied by ensemble and single-molecule FRET.

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Kalinka Hansen