Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Wang, X., Sun, F., Yin, G., Wang, Y., Liu, B. & Dong, M. (2018). Tactile-sensing based on flexible PVDF nanofibers via electrospinning: A review. Sensors (Switzerland), 18(2), Article 330. https://doi.org/10.3390/s18020330

Moein Moghimi, S. & Howard, K. (2018). Targeting Biological Barriers. Molecular Therapy, 26(4), 933-934. https://doi.org/10.1016/j.ymthe.2018.03.008

Nielsen, K. H. (2018). Teknologi. Weekendavisen, Sektion 4 (Ideer), 10.

Haydell, M. W., Centola, M., Adam, V., Valero Moreno, J. & Famulok, M. (2018). Temporal and Reversible Control of a DNAzyme by Orthogonal Photoswitching. Journal of the American Chemical Society, 140(49), 16868-16872. https://doi.org/10.1021/jacs.8b08738

Nielsen, K. H. (2018). Tesla. Weekendavisen, Sektion 4 (Ideer), 10.

Nielsen, K. H. (2018). Thalidomid. Weekendavisen, Sektion 4 (Ideer), 10.

Wang, Z., Li, Q., Chen, Y., Cui, B., Li, Y., Besenbacher, F. & Dong, M. (2018). The ambipolar transport behavior of WSe₂ transistors and its analogue circuits. NPG Asia Materials, 10(8), 703-712. https://doi.org/10.1038/s41427-018-0062-1

Berdyugina, S. V., Kuhn, J. R., Langlois, M., Moretto, G., Krissansen-Totton, J., Catling, D., Grenfell, J. L., Santl-Temkiv, T., Finster, K., Tarter, J., Marchis, F. & Apai, D. (2018). The Exo-Life Finder (ELF) telescope: New strategies for direct detection of exoplanet biosignatures and technosignatures. In Ground-based and Airborne Telescopes VII (Vol. 10700). SPIE - International Society for Optical Engineering. https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10700/107004I/The-Exo-Life-Finder-ELF-telescope--New-strategies-for/10.1117/12.2313781.short?SSO=1

Bell, J. S., Hayes, S., Whitford, C., Sanchez-Weatherby, J., Shebanova, O., Vergari, C., Winlove, C. P., Terrill, N., Sorensen, T., Elsheikh, A. & Meek, K. M. (2018). The hierarchical response of human corneal collagen to load. Acta Biomaterialia, 65, 216-225. https://doi.org/10.1016/j.actbio.2017.11.015

Röcker, A. E., Müller, J. A., Dietzel, E., Harms, M., Krüger, F., Heid, C., Sowislok, A., Riber, C. F., Kupke, A., Lippold, S., von Einem, J., Beer, J., Knöll, B., Becker, S., Schmidt-Charnasit, J., Otto, M., Vapalahti, O., Zelikin, A. N., Bitan, G. ... Münch, J. (2018). The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. Antiviral Research, 152, 26-35. https://doi.org/10.1016/j.antiviral.2018.02.003

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