Single Protein-Mediated Vesicle Division

Publications

Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

Sort by: Date | Author | Title

Hirsch, C. P., Otto, M. & Svane, A. M. (2024). NORMAL APPROXIMATION FOR GIBBS PROCESSES VIA DISAGREEMENT COUPLINGS. https://doi.org/10.1214/25-EJP1351

Wang, J., Zhang, W., Wu, T., Chen, M. & Dong, M. (2024). Occurrence of giant plasma bubble in liquid. Matter, 7(9), 3024-3035. https://doi.org/10.1016/j.matt.2024.04.032

Botnan, M. B. & Hirsch, C. (2024). On the consistency and asymptotic normality of multiparameter persistent Betti numbers. Journal of Applied and Computational Topology, 8(6), 1465-1502. https://doi.org/10.1007/s41468-022-00110-9

Lagido, C., Nielsen, K. H., Kragh, G., Flohr, P., Bezuidenhout, L., Brinkman, L., Baini, A., Saviane, C., Salnikova, A., Brandstetter-Kunc, A., Consolini, G., Correia, A., Moura, P., Fedeli, M., England, J., Venkataraman, S., Skarvøy, A., Konach, T., Taraj, B. ... Haklay, M. (2024). Open Educational Resources on Open Science and Responsible Research and Innovation (Open RRI). In EDULEARN24 Proceedings: 16th International Conference on Education and New Learning Technologies Palma, Spain. 1-3 July, 2024 (pp. 6745-6751). International Association of Technology, Education and Development (IATED). https://doi.org/10.21125/edulearn.2024.1601

Xin, Z., Kou, J., Luo, M., Liu, Q., Carraro, M., Dong, M., Daasbjerg, K., Skrydstrup, T. & Huang, Y. (2024). Open frame-like Co-Fe oxides superstructures for highly efficient cross-dehydrogenative coupling reaction of N-phenyltetrahydroisoquinoline under mild conditions. Inorganic Chemistry Communications, 170(2), Article 113352. https://doi.org/10.1016/j.inoche.2024.113352

Nielsen, K. H. (2024). Operation flere babyer. Weekendavisen, Sektion 4 (Ideer), 5.

Xiong, X., Wu, F., Ouyang, Y., Liu, Y., Wang, Z., Tian, H. & Dong, M. (2024). Oxygen Incorporated MoS₂ for Rectification-Mediated Resistive Switching and Artificial Neural Network. Advanced Functional Materials, 34(15), Article 2213348. https://doi.org/10.1002/adfm.202213348

Peeters, E., Habart, E., Berné, O., Sidhu, A., Chown, R., Van De Putte, D., Trahin, B., Schroetter, I., Canin, A., Alarcón, F., Schefter, B., Khan, B., Pasquini, S., Tielens, A. G. G. M., Wolfire, M. G., Dartois, E., Goicoechea, J. R., Maragkoudakis, A., Onaka, T. ... Zhen, J. (2024). PDRs4All: III. JWST's NIR spectroscopic view of the Orion Bar. Astronomy and Astrophysics, 685, Article A74. https://doi.org/10.1051/0004-6361/202348244

Chown, R., Sidhu, A., Peeters, E., Tielens, A. G. G. M., Cami, J., Berné, O., Habart, E., Alarcón, F., Canin, A., Schroetter, I., Trahin, B., Van De Putte, D., Abergel, A., Bergin, E. A., Bernard-Salas, J., Boersma, C., Bron, E., Cuadrado, S., Dartois, E. ... Zhen, J. (2024). PDRs4All: IV. An embarrassment of riches: Aromatic infrared bands in the Orion Bar. Astronomy and Astrophysics, 685, Article A75. https://doi.org/10.1051/0004-6361/202346662

Habart, E., Peeters, E., Berné, O., Trahin, B., Canin, A., Chown, R., Sidhu, A., De Putte, D. V., Alarcón, F., Schroetter, I., Dartois, E., Vicente, S., Abergel, A., Bergin, E. A., Bernard-Salas, J., Boersma, C., Bron, E., Cami, J., Cuadrado, S. ... Zhen, J. (2024). PDRs4All II. JWST’s NIR and MIR imaging view of the Orion Nebula. Astronomy and Astrophysics, 685, Article A73. https://doi.org/10.1051/0004-6361/202346747

Displaying results 331 to 340 out of 3464