Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Nørnberg, P., Merrison, J. P., Finster, K., Folkmann, F., Gunnlaugsson, H. P., Hansen, A., Jensen, A. M., Kinch, K., Lomstein, B. A. & Mugford, R. (2002). Simulation of martian surface conditions and dust transport. Paper presented at Graz, Austria, 16-19 September (ESA SP-518,November 2002).

Merrison, J. P., Finster, K., Gunnlaugsson, H. P., Jensen, A. M., Kinch, K., Lomstein, B. A., Mugford, R. & Nørnberg, P. (2002). Simulation results from the University of Aarhus. Paper presented at Graz, Austria, 16-19 September 2002.

Brodal, G. S., Lyngsø, R. B., Östlin, A. & Pedersen, C. N. S. (2002). Solving the String Statistics Problem in Time O(n log n). In P. Widmayer, S. Eidenbenz, F. Triguero, R. Morales, R. Conejo & M. Hennessy (Eds.), Automata, Languages and Programming: 29th International Colloquium, ICALP 2002 Málaga, Spain, July 8–13, 2002 Proceedings (pp. 728-739). Springer. https://doi.org/10.1007/3-540-45465-9_62

Hobolth, A. (2002). Statistical shape analysis of featureless objects. Department of Mathematical Sciences, Aarhus University.

Hobolth, A. & Jensen, E. B. V. (2002). Stereological analysis of shape. Image Analysis and Stereology, 21(4), S23-S29. https://doi.org/10.5566/ias.v21.pS23-S29

Hansen, A., Nørnberg, P., Merrison, J. P., Lomstein, B. A. & Finster, K. (2002). A Simulation Facility for Biological Experiments (poster A37). Proceedings of the 2nd European Workshop on Exo/Astrobiology, 461-462.

Lomstein, B. A., Hansen, A., Merrison, J. P., Nørberg, P. & Finster, K. (2002). Survival, activity and diversity of microbial communities in a Mars simulation environment. Paper presented at Graz, Austria, 16-19 September 2002.

Lyngsø, R. B. & Pedersen, C. N. S. (2002). The Consensus String Problem and the Complexity of Comparing Hidden Markov Models. Journal of Computer and System Sciences, 65(3), 545-569.

Nilsson, J., Weis, K. & Kjems, J. (2002). The C-terminal extension of the small GTPase Ran is essential for defining the GDP-bound form. J. Mol. Biol., 318, 583-593.

Nedergaard, R., Risgaard-Petersen, N. & Finster, K. (2002). The importance of sulfate reduction associated with Ulva lactuca thalli during decomposition: a mesocosm experiment. Journal of Experimental Marine Biology and Ecology, 275, 15-29. http://www.elsevier.com/locate/jembe

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