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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Hobolth, A., Guo, Q., Kousholt, A. & Jensen, J. L. (2020). A Unifying Framework and Comparison of Algorithms for Non-negative Matrix Factorisation. International Statistical Review, 88(1), 29-53. https://doi.org/10.1111/insr.12331

Nielsen, B. S., Møller, T. & Kjems, J. (2020). Automated One-Double-Z Pair BaseScope™ for CircRNA In Situ Hybridization. In B. Schnack Nielsen & J. Jones (Eds.), In Situ Hybridization Protocols (pp. 379-388). Humana Press, Inc.. https://doi.org/10.1007/978-1-0716-0623-0_24

Ramsay, E., Raviña, M., Sarkhel, S., Hehir, S., Cameron, N. R., Ilmarinen, T., Skottman, H., Kjems, J., Urtti, A., Ruponen, M. & Subrizi, A. (2020). Avoiding the pitfalls of siRNA delivery to the retinal pigment epithelium with physiologically relevant cell models. Pharmaceutics, 12(7), Article 667. https://doi.org/10.3390/pharmaceutics12070667

Nielsen, N. S., Poulsen, E. T., Lukassen, M. V., Chao Shern, C., Mogensen, E. H., Weberskov, C. E., DeDionisio, L., Schauser, L., Moore, T. C. B., Otzen, D. E., Hjortdal, J. & Enghild, J. J. (2020). Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies. Progress in Retinal and Eye Research, 77, Article 100843. https://doi.org/10.1016/j.preteyeres.2020.100843

Tian, X., Chen, X., Feng, Y., Duan, Y., Dong, M., Pan, G. & Liu, L. (2020). Biomimetic fabrication of dynamic biointerfaces with optional and diversified bioactivities through reversible covalent and bioorthogonal chemistry. Chemical Engineering Journal, 398, Article 125620. https://doi.org/10.1016/j.cej.2020.125620

Yoshimoto, R., Rahimi, K., Hansen, T. B., Kjems, J. & Mayeda, A. (2020). Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats. iScience, 23(7), Article 101345. https://doi.org/10.1016/j.isci.2020.101345

Just, J., Yan, Y., Farup, J., Sieljacks, P., Sloth, M., Venø, M., Gu, T., de Paoli, F. V., Nyengaard, J. R., Bæk, R., Jørgensen, M. M., Kjems, J., Vissing, K. & Drasbek, K. R. (2020). Blood flow-restricted resistance exercise alters the surface profile, miRNA cargo and functional impact of circulating extracellular vesicles. Scientific Reports, 10(1), Article 5835. https://doi.org/10.1038/s41598-020-62456-3

Liu, D., Geary, C. W., Chen, G., Shao, Y., Li, M., Mao, C., Andersen, E. S., Piccirilli, J. A., Rothemund, P. W. K. & Weizmann, Y. (2020). Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures. Nature Chemistry, 12(3), 249-259. https://doi.org/10.1038/s41557-019-0406-7

Carlevaro-Fita, J., Lanzós, A., Feuerbach, L., Hong, C., Mas-Ponte, D., Pedersen, J. S., PCAWG Drivers and Functional Interpretation Group, Johnson, R. & PCAWG Consortium (2020). Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Communications Biology, 3(1), Article 56. https://doi.org/10.1038/s42003-019-0741-7

Müller, C. A., Jørgensen, M. L. & Chen, M. (2020). Can Filtration Technology Advance Culture of Circulating Tumor Cells towards Precision Medicine? Archives of Cancer Biology and Therapy, 1(3). https://www.scientificarchives.com/article/can-filtration-technology-advance-culture-of-circulating-tumor-cells-towards-precision-medicine

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Kalinka Hansen