Single Protein-Mediated Vesicle Division

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Recent research news on Artificial Biology

The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′-triphosphate consumption and flipping of 2-dioleoyl-sn-glycero-3-phospho-l-serine lipids from the inner to the outer leaflet. This induced transmembrane asymmetry results in constriction and division of the giant hybrid vesicles.

4 September 2025 by Emilia Djomina Hansen

A collaborative study between the Lyons and Stadler labs, published in Advanced Materials, reports the successful reconstitution of the Drs2p–Cdc50p lipid flippase in polymer–lipid hybrid vesicles, enabling active translocation of negatively charged lipids to establish transmembrane asymmetry. Crucially, the chemical nature of the hydrophobic block in the amphiphilic block copolymers determines the curvature changes that drive vesicle constriction and division. This work marks an important step toward constructing synthetic systems capable of protein-mediated division, advancing the goal of bottom-up self-replicating assemblies.

Read the article published in Advanced Marterials here.

Contact information:
Professor Brigitte Maria Städler
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: bstadler@inano.au.dk

Tenure track Assistant Professor Joseph Lyons
Aarhus University
Interdisciplinary Nanoscience Center (iNANO)
Email: lyons@inano.au.dk

Recent publications by network

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Tørring, T. (2011). Controlling Function and Structure with DNA.

Bald, I., Wang, Y.-G., Dong, M., Rosen, C. B., Ravnsbaek, J. B., Zhuang, G.-L., Gothelf, K. V., Wang, J.-G. & Besenbacher, F. (2011). Control of Self-Assembled 2D Nanostructures by Methylation of Guanine. Small, 7(7), 939-49. https://doi.org/10.1002/smll.201002033

Wiklund, E. D., Bramsen, J. B., Hulf, T., Andersen, L. D., Ramanathan, R., Hansen, T. B., Villadsen, S. B., Gao, S., Ostenfeld, M. S., Borre, M., Peter, M. E., Ørntoft, T. F., Kjems, J. & Clark, S. J. (2011). Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer. International Journal of Cancer, 128(6), 1327-1334. https://doi.org/10.1002/ijc.25461

Ebbesen, M. (2011). Cross Cultural Principles for Bioethics. In G. D. Gargiulo & A. McEwan (Eds.), Advanced Biomedical Engineering (pp. 207-215). INTECH. https://doi.org/10.5772/18420

Nielsen, K. H. (2011). Danske videnskabscaféer - på japansk! Videnskab.dk. http://videnskab.dk/blog/danske-videnskabscafeer-pa-japansk

Chandrawati, R., Chong, S.-F., Zelikin, A. N., Rigau, L. H., Stadler, B. & Caruso, F. (2011). Degradation of liposomal subcompartments in PEGylated capsosomes. Soft Matter, 8, 9638-9646.

Finster, K. (2011). Desulfocapsa sp., sulfur disproportionation as a model of a chemolithoautotrophic "LUCA". Abstract from ISSM 2011 Microbial life below our feet, Garmisch-Partenkirchen , Germany.

Nielsen, K. H. (2011). Detachment, death, and destruction in Gerhard Richter’s Strontium (2004). History and Technology, 27(4), 455-459. https://doi.org/10.1080/07341512.2011.622156

Sturm, G. J., Bokanovic, D., Aberer, W., Hemmer, W., Hawranek, T., Lang, R., Ollert, M., Spillner, E. & Blank, S. (2011). Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy. Journal of Allergy and Clinical Immunology, 128(1), 247-248. https://doi.org/10.1016/j.jaci.2011.02.021

Song, J., Chen, M., Olesen, M. B., Wang, C., Havelund, R., Li, Q., Xie, E., Yang, R., Bøggild, P., Wang, C., Besenbacher, F. & Dong, M. (2011). Direct electrospinning of Ag/polyvinylpyrrolidone nanocables. Nanoscale, 3(12), 4966-4971. https://doi.org/10.1039/c1nr10512d

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