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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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López Hernández, M., Pedersen, J. S. & Otzen, D. E. (2023). Proteins and biosurfactants: Structures, functions, and recent applications. Current Opinion in Colloid & Interface Science, 68, Article 101746. https://doi.org/10.1016/j.cocis.2023.101746

Nielsen, K. H. (2023). Psykedelisk genfødsel. Weekendavisen, Sektion 4 (Ideer), 5.

Schiølin, K. (2023). Research handbook on law and technology: Exploring the intersection between science and technology studies and law. In B. B. Brożek, O. Kanevskaia & P. Palka (Eds.), Research Handbook on Law and Technology (pp. 365-378). Edward Elgar Publishing. https://doi.org/10.4337/9781803921327

Nielsen, K. H. (2023). Review: : Science & theatre: communication, concepts, contexts, and cases. Journal of Science Communication, 22(01), Article R03. https://doi.org/10.22323/2.22010703

Fu, S. & Nielsen, K. H. (2023). Reviving natural history, building ecological civilisation: the philosophy and social significance of the Natural History Revival Movement in contemporary China. Humanities & Social Sciences Communications, 10(1), Article 377. https://doi.org/10.1057/s41599-023-01889-3

Sampedro Vallina, N., McRae, E. K. S., Hansen, B. K., Boussebayle, A. & Andersen, E. S. (2023). RNA origami scaffolds facilitate cryo-EM characterization of a Broccoli-Pepper aptamer FRET pair. Nucleic Acids Research, 51(9), 4613-4624. https://doi.org/10.1093/nar/gkad224

Kretsch, R. C., Andersen, E. S., Bujnicki, J. M., Chiu, W., Das, R., Luo, B., Masquida, B., McRae, E. K. S., Schroeder, G. M., Su, Z., Wedekind, J. E., Xu, L., Zhang, K., Zheludev, I. N., Moult, J. & Kryshtafovych, A. (2023). RNA target highlights in CASP15: Evaluation of predicted models by structure providers. Proteins: Structure, Function and Bioinformatics, 91(12), 1600-1615. https://doi.org/10.1002/prot.26550

Nielsen, K. H. (2023). Rømers tøven. Weekendavisen, Sektion 4 (Ideer), 5.

Gouyon, J.-B., Turbil, C., Kohlt, F., Nielsen, K. H. & Sleigh, C. (2023). Science communication and scientism: historical perspectives. In M. W. Bauer & B. Schiele (Eds.), Science communication: taking a step back to move forward (pp. 385-396). CNRS Editions.

Borup, K. & Andersen, L. N. (2023). Self-Distillation for Gaussian Process Models. https://arxiv.org/pdf/2304.02641.pdf

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