Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

Xu, R., Gao, J., Cao, C., Shi, M., Zhang, Y., Hong, S., Guo, S., Chen, M., Song, P., Fu, G., Li, J., Liang, T., Miao, Y., Tang, L., Yang, J., Li, N. & Dong, M. (2023). HDL mimetics protect Alzheimer's patients carrying APOE ε4 from SARS-CoV-2 invasion. Nano Today, 53, Article 102051. https://doi.org/10.1016/j.nantod.2023.102051

Zhou, X., Rahimi, K., Kjems, J. & Lin, L. (2023). High-resolution RNA isoform variation analysis by combining the advantages of single-cell RNA and nanopore sequencing. 44. Abstract from Neuroscience Day, Aarhus, Denmark.

Nielsen, K. H. (2023). Hitler-billen. Weekendavisen, 5.

Kaarsted, T., Blake, O., Nielsen, K. H., Alving, B., Rasmussen, L. T., Denmark, U. & Hansen, S. M.-B. (2023). How European Research Libraries Can Support Citizen-Enhanced Open Science. Open Information Science, 7(1), Article 20220146. https://doi.org/10.1515/opis-2022-0146

Wu, R., Wang, Z., Jia, Z., Li, C., Wang, J., Liu, L. & Dong, M. (2023). Identification of hybrid amyloid strains assembled from amyloid-β and human islet amyloid polypeptide. Nanotechnology, 34(50), Article 505101. https://doi.org/10.1088/1361-6528/acf3ee

Busk, M., Eggertsen, P. P., Overgaard, J., Horsman, M. R., Tørring, T., Jacobsen, K. M. & Poulsen, T. B. (2023). In Vitro Characterization of the Bacteria-derived Hypoxia-selective Cytotoxin BE-₄₃₅₄₇. Anticancer Research, 43(12), 5319-5329. https://doi.org/10.21873/anticanres.16735

Wedge, E., Ahmadov, U., Hansen, T. B., Gao, Z., Tulstrup, M., Côme, C., Nonavinkere Srivatsan, S., Ahmed, T., Jespersen, J. S., Schlotmann, B. C., Schöllkopf, C., Raaschou-Jensen, K., Ødum, N., Kjems, J., Bak, R. O., Walter, M. J., Grønbæk, K. & Kristensen, L. S. (2023). Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms. Leukemia, 37(5), 1113-1125. https://doi.org/10.1038/s41375-023-01866-4

Amin, H., Šantl-Temkiv, T., Cramer, C., Finster, K., Real, F. G., Gislason, T., Holm, M., Janson, C., Jögi, N. O., Jogi, R., Malinovschi, A., Marshall, I. P. G., Modig, L., Norbäck, D., Shigdel, R., Sigsgaard, T., Svanes, C., Thorarinsdottir, H., Wouters, I. M. ... Bertelsen, R. J. (2023). Indoor Airborne Microbiome and Endotoxin: Meteorological Events and Occupant Characteristics Are Important Determinants. Environmental Science & Technology, 57(32), 11750-11766. https://doi.org/10.1021/acs.est.3c01616

Nielsen, K. H. (2023). Inficeret med misinformation. Weekendavisen, Sektion 4 (Ideer), 13.

Hirsch, C., Holmes, M. & Kleptsyn, V. (2023). Infinite WARM graphs III: Strong reinforcement regime. Nonlinearity, 36(6), 3013-3042. https://doi.org/10.1088/1361-6544/acc9a0

Displaying results 511 to 520 out of 3517