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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2022). Mekaniske tyrkere. Weekendavisen, Sektion 4 (Ideer), 5.

Brodszkij, E., Westensee, I. N., Holleufer, S. F., Ade, C., Andres, P. D. D., Pedersen, J. S. & Städler, B. (2022). Membrane composition of polymer-lipid hybrid vesicles. Applied Materials Today, 29, Article 101549. https://doi.org/10.1016/j.apmt.2022.101549

Nielsen, K. H. (2022). Mendels ærteplanter. Weekendavisen, Sektion 4 (Ideer), 5.

Nørnberg, P., Finster, K., Thøgersen, J., Golbek, T. W., Weidner, T., Hassenkam, T., Goetz, W., Oehlke, M. & Knak Jensen, S. J. (2022). Methane as a reddish coating agent. Icarus, 382, Article 115023. https://doi.org/10.1016/j.icarus.2022.115023

Kolchev, I., Marshall, I. P. G., Jones, E., Yde, J. C., Nørnberg, P., Rivera, A. M., Hodson, A. J., Bak, E. N. & Finster, K. (2022). Microbial iron reduction and greenhouse gas production in response to organic matter amendment and temperature increase of periglacial sediments, Bolterdalen, Svalbard. Arctic, Antarctic, and Alpine Research, 54(1), 314-334. https://doi.org/10.1080/15230430.2022.2097757

Ade, C., Marcelino, T. F., Dulchavsky, M., Wu, K., Bardwell, J. C. A. & Städler, B. (2022). Microreactor equipped with naturally acid-resistant histidine ammonia lyase from an extremophile. Materials Advances, 3(8), 3649-3662. https://doi.org/10.1039/d2ma00051b

Eriksen, C. B. (2022). Microscopy in Early Modern Natural Philosophy. In D. Jalobeanu & C. T. Wolfe (Eds.), Encyclopedia of Early Modern Philosophy and the Sciences (pp. 1332-1343). Springer. https://doi.org/10.1007/978-3-319-31069-5_151

Raza, U., Oh, S., Tabassian, R., Mahato, M., Hiep Nguyen, V. & Oh, I.-K. (2022). Micro-Structured Porous Electrolytes for Highly Responsive Ionic Soft Actuators. Sensors and Actuators B: Chemical, 352(Part 1), Article 131006. https://doi.org/10.1016/j.snb.2021.131006

Zhao, J., Zhang, Y., Zhang, X., Li, C., Du, H., Sønderskov, S. M., Mu, W., Dong, M. & Han, X. (2022). Mimicking Cellular Metabolism in Artificial Cells: Universal Molecule Transport across the Membrane through Vesicle Fusion. Analytical Chemistry, 94(9), 3811-3818. https://doi.org/10.1021/acs.analchem.1c04696

Sønderby, T. V., Zou, Y., Wang, P., Wang, C. & Otzen, D. E. (2022). Molecular-level insights into the surface-induced assembly of Functional Bacterial Amyloid. Biophysical Journal, 121(18), 3422-3434. https://doi.org/10.1016/j.bpj.2022.08.013

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Kalinka Hansen