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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Fang, X., Wang, Z., Kang, S., Zhao, L., Jiang, Z. & Dong, M. (2020). Hexagonal CoSe2 nanosheets stabilized by nitrogen-doped reduced graphene oxide for efficient hydrogen evolution reaction. International Journal of Hydrogen Energy, 45(3), 1738-1747. https://doi.org/10.1016/j.ijhydene.2019.11.059
Nielsen, K. H. (2020). Hvem tilhører Den Gamle? Weekendavisen, (Sektion 4 (Ideer)), 5.
Feng, Q., Hong, Y., Pradeep Nidamanuri, N., Yang, C., Li, Q. & Dong, M. (2020). Identification and Nanomechanical Characterization of the HIV Tat-Amyloid β Peptide Multifibrillar Structures. Chemistry - A European Journal, 26(43), 9449-9453. https://doi.org/10.1002/chem.201905715
Li, Y., Nidamanuri, N. P., Jiang, A., Wang, Z., Li, Q. & Dong, M. (2020). In situ construction of tandem nitrogen-doped MoP nanocrystals for high-efficient electrocatalytic hydrogen evolution. Electrochimica Acta, 342, Article 136059. https://doi.org/10.1016/j.electacta.2020.136059
Omer, M., Andersen, V. L., Nielsen, J. S., Wengel, J. & Kjems, J. (2020). Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds. Molecular Therapy - Nucleic Acids, 22, 994-1003. https://doi.org/10.1016/j.omtn.2020.10.013
Li, D., Sun, X., Gao, C. & Dong, M. (2020). Improved water flux and antifouling properties of cardo poly(aryl ether ketone) ultrafiltration membrane by novel sulfobetaine polyimides additive. Separation and Purification Technology, 251, Article 117144. https://doi.org/10.1016/j.seppur.2020.117144
Conzelmann, C., Müller, J. A., Perkhofer, L., Sparrer, K. M. J., Zelikin, A. N., Münch, J. & Kleger, A. (2020). Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Clinical Medicine, 20(6), e218-e221. https://doi.org/10.7861/clinmed.2020-0351
Eskandari, H., Ghanadian, M., Noleto-Dias, C., Lomax, C., Tawfike, A., Christiansen, G., Sutherland, D. S., Ward, J. L., Mohammad-Beigi, H. & Otzen, D. E. (2020). Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides. ACS Chemical Neuroscience, 11(19), 3161–3173. https://doi.org/10.1021/acschemneuro.0c00528
Strecker, C., Bärenfänger, M., Miehe, M., Spillner, E. & Meyer, B. (2020). In Silico Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to Synthesize an Inhibitor with Drug-Like Properties. ChemBioChem, 21(13), 1923-1931. https://doi.org/10.1002/cbic.201900289
Sun, D., Zhang, Y., Liu, Y., Wang, Z., Chen, X., Meng, Z., Kang, S., Zheng, Y., Cui, L., Chen, M., Dong, M. & Hu, B. (2020). In-situ homodispersely immobilization of Ag@AgCl on chloridized g-C3N4 nanosheets as an ultrastable plasmonic photocatalyst. Chemical Engineering Journal, 384, Article 123259. https://doi.org/10.1016/j.cej.2019.123259

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Revised 03.03.2026
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Kalinka Hansen