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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2004). Turner og tidens naturvidenskab. Billedkunst.

Sand-Jensen, K., Kjaer, C. R., Dahlgaard, J. & Andersen, E. S. (2004). Ud af osteklokken. Biozoom, Årgang 7(2).

Schrøder, H. & Andersen, E. S. (2004). Værdikampen og naturvidenskaberne. Aktuel Naturvidenskab, (2).

Ebbesen, M. & Ebbesen, F. (2003). Alternativ behandling - En videnskab, en samarbejdspartner? Månedsskr. prakt. lægegerning, 81, 1333-1338.

Ebbesen, M. & Ebbesen, F. (2003). Alternativ behandling - En videnskab, en samarbejdspartner? Månedskrift for Praktisk Lægegerning, 1333-1338.

Nielsen, K. B., Sinnathamby, T., Cartegni, L., Corydon, T. J., Kjems, J., Krainer, A. R., Elpeleg, O., Gregersen, N. & Andresen, B. S. (2003). A missense mutation found in patients with MCAD deficiency inactivates an exonic splicing enhancer in the MCAD gene. Poster session presented at Annual Meeting of the RNA society, Wien.

Freund, M., Asang, C., Kammler, S., Konermann, C., Krummheuer, J., Hipp, M., Meyer, I., Gierling, W., Theiss, S., Preuss, T., Schindler, D., Kjems, J. & Schaal, H. (2003). A novel approach to describe a U1 snRNA binding site. Nucleic Acids Research, 31(23), 6963-6975. https://doi.org/10.1093/nar/gkg901

Besenbacher, F., Kjems, J. & Andersen, E. S. (2003). Biomolekyler visualiseret med scanning probe mikroskopi. In Carlsberg Årsskrift 2003 (pp. 52-57)

Brodal, G. S., Fagerberg, R., Östlin, A., Pedersen, C. N. S. & Rao, S. S. (2003). Computing Refined Buneman Trees in Cubic Time. In G. Benson & R. Page (Eds.), Algorithms in Bioinformatics: Third International Workshop, WABI 2003, Budapest, Hungary, September 15-20, 2003. Proceedings (pp. 259-270). Springer. https://doi.org/10.1007/978-3-540-39763-2_20

Brodal, G. S., Fagerberg, R. & Pedersen, C. N. S. (2003). Computing the Quartet Distance Between Evolutionary Trees in Time O(n log n). Algorithmica, 38(2), 377-395. https://doi.org/10.1007/s00453-003-1065-y

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