Find

AUNAB - Aarhus University Network on Artificial Biology

Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

Gadeberg, T. A. F., Jørgensen, M. H., Olesen, H. G., Lorentzen, J., Harwood, S. L., Almeida, A. V., Fruergaard, M. U., Jensen, R. K., Kanis, P., Pedersen, H., Tranchant, E., Petersen, S. V., Thøgersen, I. B., Kragelund, B. B., Lyons, J. A., Enghild, J. J. & Andersen, G. R. (2025). Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring. Nature Structural and Molecular Biology, 32(5), 884-895. Article 872536. https://doi.org/10.1038/s41594-024-01467-4

Li, B., Xu, M., Zhang, D., Zhang, Y., Li, Q. & Dong, M. (2025). Current-carrying friction of atomically thin molybdenum disulfide. Applied Surface Science, 685, Article 162021. https://doi.org/10.1016/j.apsusc.2024.162021

Nielsen, K. H. (2025). DEI-fri forskning. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2025). Den lange kamp om lymfekarrene. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2025). Den moralske fare ved gratis lægehjælp. Weekendavisen, Sektion 4 (Ideer), 5.

Tang, Y., Friec, A. L., Chen, M. & Sun, D. (2025). Designed Biomaterial-Enhanced Cell Transplantation for Neural Tissue Engineering. Aggregate, 6(5), Article e70022. https://doi.org/10.1002/agt2.70022

Kjær, M. B., Jørgensen, A. G., Fjelstrup, S., Dupont, D. M., Bus, C., Eriksen, P. L., Thomsen, K. L., Risikesan, J., Nielsen, S., Wernberg, C. W., Lauridsen, M. M., Bugianesi, E., Rosso, C., Grønbæk, H. & Kjems, J. (2025). Diagnosis and Staging of Metabolic Dysfunction-Associated Steatotic Liver Disease Using Biomarker-Directed Aptamer Panels. Biomolecules, 15(2), Article 255. https://doi.org/10.3390/biom15020255

Nybo, T., Gamon, L. F., Fuentes-Lemus, E., Otzen, D. E., Davies, M. J. & Hägglund, P. (2025). Dimethyl labeling of N-terminal amines allows unambiguous identification of protein crosslinks. Free Radical Biology & Medicine, 227, 629-637. https://doi.org/10.1016/j.freeradbiomed.2024.12.002

Kang, H., Niu, L., Zhang, F., Qing, C., Tong, H., Guan, L., Zhang, M., Liu, Z., Deng, G. & Dong, M. (2025). Direct Spraying of Large-Scale Nanofiber Air Filters for Highly Efficient Particulate Matter Removal. Langmuir, 41(48), 32902-32910. https://doi.org/10.1021/acs.langmuir.5c05019

De Dios Andres, P., Akter, M., Ryberg, C., Städler, B. & Liu, A. P. (2025). Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles. Advanced Biology, 9(5), Article 2400601. https://doi.org/10.1002/adbi.202400601

Displaying results 141 to 150 out of 3517

15

Revised 03.03.2026

-

Kalinka Hansen