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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2018). Book Review: Helga Nowotny, The cunning of uncertainty. Public Understanding of Science, 260.

Li, S., Zhu, T., Dong, L. & Dong, M. (2018). Boosted visible light photodegradation activity of boron doped rGO/g-C₃N₄ nanocomposites: the role of C-O-C bonds. New Journal of Chemistry, 42(21), 17644-17651. https://doi.org/10.1039/c8nj03571g

Gao, S., Hu, X., Xu, F., Gao, C., Xiong, K., Zhao, X., Chen, H., Zhao, S., Wang, M., Fu, D., Zhao, X., Bai, J., Mao, L., Li, B., Wu, S., Wang, J., Li, S., Yang, H., Bolund, L. & Pedersen, C. N. S. (2018). BS-virus-finder: virus integration calling using bisulfite sequencing data. GigaScience, 7(1), 1-7. https://doi.org/10.1093/gigascience/gix123

Song, W., Yang, C., Svend Le, D. Q., Zhang, Y. & Kjems, J. (2018). Calcium-microRNA Complexes Functionalized Nanotubular Implant Surface for Highly Efficient Transfection and Enhanced Osteogenesis of Mesenchymal Stem Cells. A C S Applied Materials and Interfaces, 10(9), 7756-7764. https://doi.org/10.1021/acsami.7b18289

Højgaard, C., Sørensen, H. V., Pedersen, J. S., Winther, J. R. & Otzen, D. E. (2018). Can a Charged Surfactant Unfold an Uncharged Protein? Biophysical Journal, 115(11), 2081-2086. https://doi.org/10.1016/j.bpj.2018.10.022

Nielsen, K. H. (2018). Cannabis. Weekendavisen, Sektion 4 (Ideer), 10.

Wang, Y., Xia, Q., Bai, X., Ge, Z., Yang, Q., Yin, C., Kang, S., Dong, M. & Li, X. (2018). Carbothermal activation synthesis of 3D porous g-C₃N₄/carbon nanosheets composite with superior performance for CO₂ photoreduction. Applied Catalysis B: Environment and Energy, 239, 196-203. https://doi.org/10.1016/j.apcatb.2018.08.018

Vu Quang, H., Chang, C.-C., Song, P., Hauge, E. M. & Kjems, J. (2018). Caveolae-mediated mesenchymal stem cell labelling by PSS-coated PLGA PFOB nano-contrast agent for MRI. Theranostics, 8(10), 2657-2671. https://doi.org/10.7150/thno.23206

Larsen, M. T., Rawsthorne, H., Schelde, K. K., Dagnæs-Hansen, F., Cameron, J. & Howard, K. (2018). Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement. Journal of Controlled Release, 287, 132-141. https://doi.org/10.1016/j.jconrel.2018.07.023

Russkamp, D., Van Vaerenbergh, M., Etzold, S., Eberlein, B., Darsow, U., Schiener, M., De Smet, L., Absmaier, M., Biedermann, T., Spillner, E., Ollert, M., Jakob, T., Schmidt-Weber, C. B., de Graaf, D. C. & Blank, S. (2018). Characterization of the honeybee venom proteins C1q-like protein and PVF1 and their allergenic potential. Toxicon, 150, 198-206. https://doi.org/10.1016/j.toxicon.2018.05.017

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Kalinka Hansen