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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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Pirhaghi, M., Najarzadeh, Z., Moosavi-Movahedi, F., Shafizadeh, M., Mamashli, F., Atarod, D., Ghasemi, A., Morshedi, D., Meratan, A. A., Otzen, D. E. & Saboury, A. A. (2023). The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production: Highlighting its antibiotic activity. Biochimica et Biophysica Acta - Proteins and Proteomics, 1871(2), Article 140883. https://doi.org/10.1016/j.bbapap.2022.140883

Reinhold, D., Farztdinov, V., Yan, Y., Meisel, C., Sadlowski, H., Kühn, J., Perschel, F. H., Endres, M., Düzel, E., Vielhaber, S., Guttek, K., Goihl, A., Venø, M., Teegen, B., Stöcker, W., Stubbemann, P., Kurth, F., Sander, L. E., Ralser, M. ... Körtvelyessy, P. (2023). The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation. Journal of Neuroinflammation, 20, Article 30. https://doi.org/10.1186/s12974-023-02711-2

Langmüller, A. M., Nolte, V., Dolezal, M. & Schlötterer, C. (2023). The genomic distribution of transposable elements is driven by spatially variable purifying selection. Nucleic Acids Research, 51(17), 9203-9213. https://doi.org/10.1093/nar/gkad635

Fu, S. & Nielsen, K. H. (2023). The humanist challenge to China’s dominant policies for popularizing science and technology (PST). Science as Culture, 32(4), 486-504. https://doi.org/10.1080/09505431.2023.2211760

Hourfar, H., Aliakbari, F., Aqdam, S. R., Nayeri, Z., Bardania, H., Otzen, D. E. & Morshedi, D. (2023). The impact of α-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells. International Journal of Biological Macromolecules, 229, 305-320. https://doi.org/10.1016/j.ijbiomac.2022.12.134

Zhang, Z., Chen, Y., Klausen, L. H., Skaanvik, S. A., Wang, D., Chen, J. & Dong, M. (2023). The Rational Design and Development of Microalgae-Based Biohybrid Materials for Biomedical Applications. Engineering, 24, 102-113. https://doi.org/10.1016/j.eng.2022.09.016

Li, Z., Liu, Q., Li, Q. & Dong, M. (2023). The role of hydrated anions in hydration lubrication. Nano Research, 16(1), 1096-1100. https://doi.org/10.1007/s12274-022-4653-3

Nielsen, K. H. (2023). The role of the media in vaccination controversies: From misinformation and misleading messages to complex and contextual understandings. Abstract from PCST Conference, Rotterdam, Netherlands. https://pcst2023.nl/wp-content/uploads/2023/04/PCST2023_BookofAbstracts_complete_April.pdf

Cipriani, A., Hirsch, C. & Vittorietti, M. (2023). Topology-based goodness-of-fit tests for sliced spatial data. Computational Statistics and Data Analysis, 179, Article 107655. https://doi.org/10.1016/j.csda.2022.107655

Schiølin, K. & Frahm, N. M. (2023). Toward an ‘Ever Closer Union’: The Making of AI-Ethics in the EU. STS Encounters , 15(2). https://doi.org/10.7146/stse.v15i2.139808

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