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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2023). Verdens ældste pyramide. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2023). Virologer på vildspor. Weekendavisen, Sektion 4 (Ideer), 5.

Jensen, B. N., Wang, Y., Friec, A. L., Nabavi, S. . M. . S., Dong, MD., Seliktar, D. & Chen, M. (2023). Wireless electromagnetic neural stimulation patch with anisotropic guidance. npj Flexible Electronics, 7(1), Article 34. https://doi.org/10.1038/s41528-023-00270-3

Andersen-Civil, A. I. S., Sawale, R. A. & Vanwalleghem, G. C. (2023). Zebrafish (Danio rerio) as a translational model for neuro-immune interactions in the enteric nervous system in autism spectrum disorders. Brain, Behavior, and Immunity, 112, 254-266. https://doi.org/10.1016/j.bbi.2023.06.001

Mahato, M., Hwang, W. J., Tabassian, R., Oh, S., Nguyen, V. H., Nam, S., Kim, J. S., Yoo, H., Taseer, A. K., Lee, M. J., Zhang, H., Song, T. E. & Oh, I. K. (2022). A Dual-Responsive Magnetoactive and Electro–Ionic Soft Actuator Derived from a Nickel-Based Metal–Organic Framework. Advanced Materials, 34(35), Article 2203613. https://doi.org/10.1002/adma.202203613

Zhu, X., Wang, Z., Gao, M., Wang, Y., Hu, J., Song, Z., Wang, Z. & Dong, M. (2022). AgPt/MoS₂ hybrid as electrochemical sensor for detecting H₂O₂ release from living cells. New Journal of Chemistry, 46(31), 15032-15041. https://doi.org/10.1039/d2nj02495k

Yang, E., Metzloff, M., Langmüller, A. M., Xu, X., Clark, A. G., Messer, P. W. & Champer, J. (2022). A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles. G3: Genes, Genomes, Genetics, 12(6), Article jkac081. https://doi.org/10.1093/g3journal/jkac081

Dinesen, A., Winther, A., Wall, A., Märcher, A., Palmfeldt, J., Chudasama, V., Wengel, J., Gothelf, K. V., Baker, J. R. & Howard, K. A. (2022). Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly. Bioconjugate Chemistry, 33(2), 333-342. https://doi.org/10.1021/acs.bioconjchem.1c00561

Fuchs, E., Rudnik-Jansen, I., Dinesen, A., Selnihhin, D., Mandrup, O. A., Thiam, K., Kjems, J., Pedersen, F. S. & Howard, K. A. (2022). An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension. Acta Biomaterialia, 153, 411-418. https://doi.org/10.1016/j.actbio.2022.09.048

Dinesen, A., Winther, A., Wall, A., Märcher, A., Palmfeldt, J., Chudasama, V., Wengel, J., Gothelf, K. V., Baker, J. R. & Howard, K. (2022). An Albumin Biomolecular Drug Design Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Assembly. Poster session presented at Controlled Release Society 2022 Annual Meeting, Montreal, Quebec, Canada.

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Kalinka Hansen