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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Pedersen, C. N. S. (2002). Bioinformatik ved Aarhus Universitet. Biozoom, (3), 12-18.

Pedersen, C. N. S., Scharling, T., Guigó, R. (Ed.) & Gusfield, D. (Ed.) (2002). Comparative Methods for Gene Structure Prediction in Homologous Sequences. In Ikke angivet (2452 of Lecture Notes in Computer Science ed., Vol. 2452/2002, pp. 220-234). Springer.

Lund, M. & Kjems, J. (2002). Defining a 5′ splice site by functional selection in the presence and absence of U1 snRNA 5′-end. RNA, 8, 166-179.

Finster, K., Jensen, A.-M., Hansen, A., Lomstein, B. A., Nørberg, P. & Merrison, J. P. (2002). Description of a Mars-simulation facility. Paper presented at Graz, Austria, 16-19 September 2002.

Finster, K., Jensen, A. M., Lomstein, B. A., Nørnberg, P. & Merrison, J. P. (2002). Description of a Mars-simulation facility. Abstract from 2nd European Workshop on Exo/Astrobiology, Graz, Austria.

Ebbesen, M. (2002). Etisk vurdering indenfor lægevidenskab og bioteknologi. Bibliotek for Læger, 194, 232-259.

Ebbesen, M. (2002). Etisk vurdering indenfor lægevidenskab og bioteknologi. Bibliotek for Læger, 232-259.

Andersen, E. S. (2002). Evolutionsteori til debat. Delfinen, (96).

Nørberg, P., Finster, K., Folkmann, F., Gunnlaugsson, H. P., Hansen, A., Kinch, K., Lomstein, B. A. & Merrison, J. P. (2002). Facility at the Mars-simulation laboratory. Paper presented at Graz, Austria, 16-19 September 2002.

Hornekær, L. & Drewsen, M. (2002). Formation process of large ion Coulomb crystals in linear Paul traps. Physical Review A, 66.

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