Find

AUNAB - Aarhus University Network on Artificial Biology

Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

Choong, F. X., Huzell, S., Rosenberg, M., Eckert, J. A., Nagaraj, M., Zhang, T., Melican, K., Otzen, D. E. & Richter-Dahlfors, A. (2021). A semi high-throughput method for real-time monitoring of curli producing Salmonella biofilms on air-solid interfaces. Biofilm, 3, Article 100060. https://doi.org/10.1016/j.bioflm.2021.100060

Valero, J., Civit, L., Dupont, D. M., Selnihhin, D., Reinert, L. S., Idorn, M., Israels, B. A., Bednarz, A. M., Bus, C., Asbach, B., Peterhoff, D., Pedersen, F. S., Birkedal, V., Wagner, R., Paludan, S. R. & Kjems, J. (2021). A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry. Proceedings of the National Academy of Sciences (PNAS), 118(50), Article e2112942118. https://doi.org/10.1073/pnas.2112942118

Zhang, Y., Zhang, D., Wang, Y., Liu, Q., Li, Q. & Dong, MD. (2021). Atomic-Scale Friction of Black and Violet Phosphorus Crystals: Implications for Phosphorus-Based Devices and Lubricants. ACS Applied Nano Materials, 4(9), 9932-9937. https://doi.org/10.1021/acsanm.1c02593

Nielsen, K. H. (2021). Atomic Urbanism under Greenland’s Ice Cap: Camp Century and Cold War Architectural Imagination. In R. Brook, M. Dodge & J. Hogg (Eds.), Cold War Cities: Politics, Culture and Atomic Urbanism, 1945-1965 (pp. 182-199). Routledge. https://doi.org/10.4324/9780203701478

Ahmed, S. Z., Hjorth, A., Rafner, J. F., Weidner, C. A., Kragh, G., Jensen, J. H. M., Bobroff, J., Nielsen, K. H. & Sherson, J. F. (2021). A training programme for early-stage researchers that focuses on developing personal science outreach portfolios. Science Communication https://doi.org/10.48550/arXiv.2103.03109

Otzen, D. E., Morshedi, D., Mohammad-Beigi, H. & Aliakbari, F. (2021). A Triple Role for a Bilayer: Using Nanoliposomes to Cross and Protect Cellular Membranes. Journal of Membrane Biology, 254(1), 29-39. https://doi.org/10.1007/s00232-020-00159-6

Wang, Z., Cui, Y., Feng, Y., Guan, L., Dong, M., Liu, Z. & Liu, L. (2021). A versatile Silk Fibroin based filtration membrane with enhanced mechanical property, disinfection and biodegradability. Chemical Engineering Journal, 426, Article 131947. https://doi.org/10.1016/j.cej.2021.131947

Mandrup, O. A. & Howard, K. (2021). Bioengineered solutions to improve cancer immunotherapies. Therapeutic Delivery, 12(5), 339-341 . https://doi.org/10.4155/tde-2021-0019

Howard, K. (2021). Biomolecular Assemblies as Multifunctional Drug Designs. In Handbook of Harnessing Biomaterials in Nanomedicine: Preparation, Toxicity, and Applications (2 ed., pp. 363-380). Jenny Stanford Publishing.

Noji, M., Samejima, T., Yamaguchi, K., So, M., Yuzu, K., Chatani, E., Akazawa-Ogawa, Y., Hagihara, Y., Kawata, Y., Ikenaka, K., Mochizuki, H., Kardos, J., Otzen, D. E., Bellotti, V., Buchner, J. & Goto, Y. (2021). Breakdown of supersaturation barrier links protein folding to amyloid formation. Communications Biology, 4(1), Article 120. https://doi.org/10.1038/s42003-020-01641-6

Displaying results 781 to 790 out of 3503

79

Revised 03.03.2026

-

Kalinka Hansen