Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., PCAWG Drivers and Functional Interpretation Working Group, Reimand, J. & PCAWG Consortium (2020). Integrative pathway enrichment analysis of multivariate omics data. Nature Communications, 11(1), Article 735. https://doi.org/10.1038/s41467-019-13983-9

Mortensen, M. R., Skovsgaard, M. B., Märcher, A., Andersen, V. L., Palmfeldt, J., Nielsen, T. B., Tørring, T., Laursen, N. S., Andersen, K. R., Kjems, J. & Gothelf, K. V. (2020). Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. Bioconjugate Chemistry, 31(5), 1295-1300. https://doi.org/10.1021/acs.bioconjchem.0c00151

Jiang, A., Wang, Z., Li, Q. & Dong, M. (2020). Ionic Liquid-Assisted Synthesis of Hierarchical One-Dimensional MoP/NPC for High-Performance Supercapacitor and Electrocatalysis. ACS Sustainable Chemistry & Engineering, 8(16), 6343-6351. https://doi.org/10.1021/acssuschemeng.0c00238

Schiølin, K., Sample, M. & Nguyen, A. (Eds.) (2020). Issue 1: Pandemic.

Nielsen, K. H. (2020). Kampen om mørketallet. Weekendavisen, (Sektion 4 (Ideer)), 5.

Nielsen, K. H. (2020, Jan 17). Klima: Tager 11.258 forskere fejl? Videnskab.dk. https://videnskab.dk/kultur-samfund/klima-tager-11258-forskere-fejl

Nielsen, K. H. (2020). Knæk kurven. Weekendavisen, (Sektion 4 (Ideer)), 13.

Thrower, J., Pantazidis, G., Scheffler, M., Simonsen, F. D. S., Jensen, P. A. & Hornekær, L. (2020). Laboratory evidence for the formation of hydrogenated fullerene molecules. In F. Salama & H. Linnartz (Eds.), Laboratory Astrophysics: From Observations to Interpretation (Vol. 15, pp. 144-147). Cambridge University Press. https://doi.org/10.1017/s1743921319007567

Liu, Z., Xu, Q., Zhang, C., Sun, Q., Wang, C., Dong, M., Wang, Z., Ohmori, H., Kosinova, M., Goto, T., Tu, R. & Zhang, S. (2020). Laser-induced growth of large-area epitaxial graphene with low sheet resistance on 4H-SiC(0001). Applied Surface Science, 514, Article 145938. https://doi.org/10.1016/j.apsusc.2020.145938

Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J. ... LifeTime Community Working Groups (2020). LifeTime and improving European healthcare through cell-based interceptive medicine. Nature, 587, 377-386. https://doi.org/10.1038/s41586-020-2715-9

Displaying results 991 to 1000 out of 3467

100