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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Santomartino, R., Waajen, A. C., de Wit, W., Nicholson, N., Parmitano, L., Loudon, C. M., Moeller, R., Rettberg, P., Fuchs, F. M., Van Houdt, R., Finster, K., Coninx, I., Krause, J., Koehler, A., Caplin, N., Zuijderduijn, L., Zolesi, V., Balsamo, M., Mariani, A. ... Cockell, C. S. (2020). No Effect of Microgravity and Simulated Mars Gravity on Final Bacterial Cell Concentrations on the International Space Station: Applications to Space Bioproduction. Frontiers in Microbiology, 11, Article 579156. https://doi.org/10.3389/fmicb.2020.579156

Alijanvand, S. H., Christensen, M. H., Christiansen, G., Harikandei, K. B., Salehi, P., Schiøtt, B., Moosavi-Movahedi, A. A. & Otzen, D. E. (2020). Novel noscapine derivatives stabilize the native state of insulin against fibrillation. International Journal of Biological Macromolecules, 147, 98-108. https://doi.org/10.1016/j.ijbiomac.2020.01.061

Basse-O’connor, A., Pedersen, J. & Rohde, V. (2020). On infinite divisibility of a class of two-dimensional vectors in the second wiener chaos. Modern Stochastics: Theory and Applications, 7(3), 267-289. https://doi.org/10.15559/20-VMSTA160

Hirsch, C. (2020). On the decomposability of mod 2 cohomological invariants of Weyl groups. Commentarii Mathematici Helvetici, 95(4), 765-809. https://doi.org/10.4171/CMH/503

Yan, Y., Chang, C., Su, J., Venø, M. T. & Kjems, J. (2020). Osteoblastogenesis Alters Small RNA Profiles in EVs Derived from Bone Marrow Stem Cells (BMSCs) and Adipose Stem Cells (ASCs). Biomedicines, 8(10), 1-17. Article 387. https://doi.org/10.3390/biomedicines8100387

Lyons, J. A., Timcenko, M., Dieudonné, T., Lenoir, G. & Nissen, P. (2020). P4-ATPases: how an old dog learnt new tricks — structure and mechanism of lipid flippases. Current Opinion in Structural Biology, 63, 65-73. https://doi.org/10.1016/j.sbi.2020.04.001

Nielsen, K. H. (2020). På den sorte liste. Weekendavisen, Sektion 4 (Ideer), 5.

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (2020). Pan-cancer analysis of whole genomes. Nature, 578(7793), 82-93. https://doi.org/10.1038/s41586-020-1969-6

Nielsen, K. H. (2020). På sikker afstand. Weekendavisen, (Sektion 4 (Ideer)), 5.

Jakob, D. S., Wang, H., Zeng, G., Otzen, D. E., Yan, Y. & Xu, X. (2020). Peak Force Infrared - Kelvin Probe Force Microscopy. Angewandte Chemie International Edition, 59(37), 16083-16090. https://doi.org/10.1002/anie.202004211

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