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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Conzelmann, C., Müller, J. A., Perkhofer, L., Sparrer, K. M. J., Zelikin, A. N., Münch, J. & Kleger, A. (2020). Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Clinical Medicine, Journal of the Royal College of Physicians of London, 20(6), e218-e221. https://doi.org/10.7861/clinmed.2020-0351

Eskandari, H., Ghanadian, M., Noleto-Dias, C., Lomax, C., Tawfike, A., Christiansen, G., Sutherland, D. S., Ward, J. L., Mohammad-Beigi, H. & Otzen, D. E. (2020). Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena: the all-pervading powers of flavonoids and phenolic glycosides. ACS Chemical Neuroscience, 11(19), 3161–3173. https://doi.org/10.1021/acschemneuro.0c00528

Strecker, C., Bärenfänger, M., Miehe, M., Spillner, E. & Meyer, B. (2020). In Silico Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to Synthesize an Inhibitor with Drug-Like Properties. ChemBioChem, 21(13), 1923-1931. https://doi.org/10.1002/cbic.201900289

Sun, D., Zhang, Y., Liu, Y., Wang, Z., Chen, X., Meng, Z., Kang, S., Zheng, Y., Cui, L., Chen, M., Dong, M. & Hu, B. (2020). In-situ homodispersely immobilization of Ag@AgCl on chloridized g-C₃N₄ nanosheets as an ultrastable plasmonic photocatalyst. Chemical Engineering Journal, 384, Article 123259. https://doi.org/10.1016/j.cej.2019.123259

Gao, Q., Zhang, J., Chen, C., Chen, M., Sun, P., Du, W., Zhang, S., Liu, Y., Zhang, R., Bai, M., Fan, C., Wu, J., Men, T. & Jiang, X. (2020). In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida albicans Infection. ACS Nano, 14(4), 3980-3990. https://doi.org/10.1021/acsnano.9b07896

Moller Sonderskov, S., Hyldgaard Klausen, L., Amland Skaanvik, S., Han, X. & Dong, M. (2020). In situ Surface Charge Density Visualization of Self-assembled DNA Nanostructures after Ion Exchange. ChemPhysChem, 21(13), 1474-1482. https://doi.org/10.1002/cphc.201901168

Paczkowska, M., Barenboim, J., Sintupisut, N., Fox, N. S., Zhu, H., Abd-Rabbo, D., Mee, M. W., Boutros, P. C., PCAWG Drivers and Functional Interpretation Working Group, Reimand, J. & PCAWG Consortium (2020). Integrative pathway enrichment analysis of multivariate omics data. Nature Communications, 11(1), Article 735. https://doi.org/10.1038/s41467-019-13983-9

Mortensen, M. R., Skovsgaard, M. B., Märcher, A., Andersen, V. L., Palmfeldt, J., Nielsen, T. B., Tørring, T., Laursen, N. S., Andersen, K. R., Kjems, J. & Gothelf, K. V. (2020). Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling. Bioconjugate Chemistry, 31(5), 1295-1300. https://doi.org/10.1021/acs.bioconjchem.0c00151

Jiang, A., Wang, Z., Li, Q. & Dong, M. (2020). Ionic Liquid-Assisted Synthesis of Hierarchical One-Dimensional MoP/NPC for High-Performance Supercapacitor and Electrocatalysis. ACS Sustainable Chemistry & Engineering, 8(16), 6343-6351. https://doi.org/10.1021/acssuschemeng.0c00238

Schiølin, K., Sample, M. & Nguyen, A. (Eds.) (2020). Issue 1: Pandemic.

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Kalinka Hansen