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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Laursen, S. H., Hansen, S. G., Taskin, M. B., Chen, M., Wogensen, L., Nygaard, J. V. & Axelsen, S. M. (2023). Electrospun nanofiber mesh with connective tissue growth factor and mesenchymal stem cells for pelvic floor repair: Long-term study. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 111(2), 392-401. https://doi.org/10.1002/jbm.b.35158

Roeters, S. J., Strunge, K., Pedersen, K. B., Golbek, T. W., Bregnhøj, M., Zhang, Y., Wang, Y., Dong, M., Nielsen, J., Otzen, D. E., Schiøtt, B. & Weidner, T. (2023). Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces. Nature Communications, 14(1), Article 5731. https://doi.org/10.1038/s41467-023-39843-1

Ye, Z., Tan, C., Huang, X., Ouyang, Y., Yang, L., Wang, Z. & Dong, M. (2023). Emerging MoS₂ Wafer-Scale Technique for Integrated Circuits. Nano-Micro Letters, 15(1), Article 38. https://doi.org/10.1007/s40820-022-01010-4

Nielsen, K. H. (2023). En pandemi af tilbagetrækninger. Weekendavisen, Sektion 4 (Ideer), 5.

Eriksen, J., Ebbesen, M., KT, E., Hjermitslev, C., Knudsen, C., Bertelsen, P., Nøhr, C. & Weber, D. (2023). Equity in digital healthcare – the case of Denmark. Frontiers in Public Health, 11, 1-6. Article 1225222. https://doi.org/10.3389/fpubh.2023.1225222

Rheinbay, E., Nielsen, M. M., Abascal, F., Wala, J. A., Shapira, O., Tiao, G., Hornshøj, H., Hess, J. M., Juul, R. I., Lin, Z., Feuerbach, L., Sabarinathan, R., Madsen, T., Kim, J., Mularoni, L., Shuai, S., Lanzós, A., Herrmann, C., Maruvka, Y. E. ... PCAWG Drivers and Functional Interpretation Working Group (2023). Erratum: Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (Nature (2020) 578 7793 (102-111)). Nature, 614(7948), E40. https://doi.org/10.1038/s41586-022-05599-9

Aagaard, J. B., Fischer, M., Lober, J., Bolbro Neumann, F., Allahverdi, D., Sivelle, C., Miehe, M. & Spillner, E. (2023). Extract-shaped immune repertoires as source for nanobody-based human IgE in grass pollen allergy. Molecular Biotechnology, 65(9), 1518-1527. https://doi.org/10.1007/s12033-023-00664-8

Nielsen, K. H. (2023). Fagfællebedømt racisme. Weekendavisen, Sektion 4 (Ideer), 5.

Rasmussen, H. Ø., Kumar, A., Shin, B., Stylianou, F., Sewell, L., Xu, Y., Otzen, D. E., Pedersen, J. S. & Matthews, S. J. (2023). FapA is an Intrinsically Disordered Chaperone for Pseudomonas Functional Amyloid FapC. Journal of Molecular Biology, 435(2), Article 167878. https://doi.org/10.1016/j.jmb.2022.167878

Nielsen, K. H. (2023). Fladjordsteori for sociologer. Weekendavisen, Sektion 4 (Ideer), 5.

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