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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Cui, L., Liu, Y., Wang, Y., Fang, X., Yin, C., Kang, S. & Dong, M. (2018). Constructing ultrathin g-C₃N₄ nanosheets with hierarchical pores by NaClO induced wet etching for efficient photocatalytic Cr(VI) detoxification under visible light irradiation. Diamond and Related Materials, 88, 51-59. https://doi.org/10.1016/j.diamond.2018.06.016

Wang, Z., Li, Q., Xu, H., Dahl-Petersen, C., Yang, Q., Cheng, D., Cao, D., Besenbacher, F., Lauritsen, J. V., Helveg, S. & Dong, M. (2018). Controllable etching of MoS₂ basal planes for enhanced hydrogen evolution through the formation of active edge sites. Nano Energy, 49, 634-643. https://doi.org/10.1016/j.nanoen.2018.04.067

Stenvang, M., Schafer, N. P., Malmos, K. G., Pérez, A.-M. W., Niembro, O., Sormanni, P., Basaiawmoit, R. V., Christiansen, G., Andreasen, M. & Otzen, D. E. (2018). Corneal dystrophy mutations drive pathogenesis by targeting TGFBIp stability and solubility in a latent amyloid-forming domain. Journal of Molecular Biology, 430(8), 1116-1140. https://doi.org/10.1016/j.jmb.2018.03.001

Li, S., Zhu, T., Dong, L. & Dong, M. (2018). Correction: Boosted visible light photodegradation activity of boron doped rGO/g-C₃N₄ nanocomposites: the role of C-O-C bonds (vol 42, pg 17644, 2018). New Journal of Chemistry, 42(23), 19305-19306. https://doi.org/10.1039/c8nj90110d

Skov, L., Hui, R., Shchur, V., Hobolth, A., Scally, A., Schierup, M. H. & Durbin, R. (2018). Detecting archaic introgression using an unadmixed outgroup. PLoS Genetics, 14(9), Article e1007641. https://doi.org/10.1371/journal.pgen.1007641

Jepsen, M. D. E., Sparvath, S. M., Nielsen, T. B., Langvad, A. H., Grossi, G., Gothelf, K. V. & Andersen, E. S. (2018). Development of a genetically encodable FRET system using fluorescent RNA aptamers. Nature Communications, 9(1), Article 18. https://doi.org/10.1038/s41467-017-02435-x

Dreier, C., Zelikin, A. N., Kjems, J. & Meyer, R. L. (2018). Development of an iron oxide nanoparticle drug delivery system against Staphylococcus aureus biofilm infections. Abstract from ICONAN2018, Rom, Italy. https://www.premc.org/doc/ICONAN2018/ICONAN2018_Book_Of_Abstracts.pdf

Wang, J., Liu, L., Ge, D., Zhang, H., Feng, Y., Zhang, Y., Chen, M. & Dong, MD. (2018). Differential Modulating Effect of MoS2 on Amyloid Peptide Assemblies. Chemistry: A European Journal, 24(14), 3397-3402. https://doi.org/10.1002/chem.201704593

Domaljanovic, I., Rexen Ulven, E., Ulven, T., Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K. (2018). Dihydropyridine fluorophores allow for specific detection of human antibodies in serum. ACS Omega, 3(7), 7580–7586. https://doi.org/10.1021/acsomega.8b00424

Fuhs, T., Klausen, L. H., Sønderskov, S. M., Han, X. & Dong, M. (2018). Direct measurement of surface charge distribution in phase separating supported lipid bilayers. Nanoscale, 10(9), 4538-4544. https://doi.org/10.1039/c7nr09522h

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Kalinka Hansen