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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Kristensen, T. G., Pedersen, C. S., Thomsen, R. & Christensen, M. H. (2009). Largest Common Chemical Feature Subtree as a Virtual Screening Method. Poster session presented at 17th Annual International Conference on Intelligent Systems for Molecular Bioligy (ISMB) & 8th European Conference on Computational Biology (ECCB), Stockholm, Sweden. http://www.iscb.org/ismbeccb2009/poster_list.php?cat=C

Nevo, I., Kapishnikov, S., Birman, A., Dong, M., Cohen, S. R., Kjaer, K., Besenbacher, F., Stapelfeldt, H., Seideman, T. & Leiserowitz, L. (2009). Laser-induced aligned self-assembly on water surfaces. Journal of Chemical Physics, 130(14), 144704. https://doi.org/10.1063/1.3108540

Basse-O'Connor, A. & Pedersen, J. (2009). Lévy driven moving averages and semimartingales. Stochastic Processes and Their Applications, 119(9), 2970-2991. https://doi.org/10.1016/j.spa.2009.03.007

Andersen, L. N. & Asmussen, S. (2009). Local time asymptotics for centered Lévy processes with two-sided reflection. Thiele Centre, Institut for Matematiske Fag, Aarhus Universitet.

Andersen, L. N. (2009). Loss Rates and Structural Properties of Reflected Stochastic Processes. Aarhus Universitetsforlag.

Dong, M. (Ed.) (2009). Materials Special Issue: Nanomaterials. In Mangler titel

Birkedal, V., Krüger, A. C., Nochyporuk-Zloy, V., Kjems, J. & Besenbacher, F. (2009). Methods for single molecule FRET microsocpy data analysis. Poster session presented at 15^th Anniversary International Workshop on "Single Molecule Spectroscopy and Ultra Sensitive Analysis in the Life Sciences", Berlin, Germany.

Cockell, C. S., Gronstal, A. L., Voytek, M. A., Kirshtein, J. D., Finster, K., Sanford, W. E., Glamoclija, M., Grohn, G. S., Powers, D. S. & Horton Jr., J. W. (2009). Microbial abundance in the deep subsurface of the Chesapeake Bay impact crater: Relationship to lithology and impact processes. Geological Society of America. Special Papers, 458, 941-950.

Bunge, M., Søbjerg, L. S., Lindhardt, A., Gauthier, D., Hyldgaard, M., Hause, G., Finster, K., Skrydstrup, T. & Meyer, R. L. (2009). Microbial formation of palladium nanocatalysts. Poster session presented at Microbial formation of palladium nanocatalysts, Göteborg, Sweden.

Nørnberg, P., Vendelboe, A. L., Gunnlaugsson, H. P., Merrison, J. P., Finster, K. & Jensen, S. K. (2009). Mineralogy after an experimental forest fire on Quaternary soil goethite/ferrihydrite, compared with a hematite, maghemite, goethite containing topsoil. Clay Minerals, 44, 239-247.

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