Find

AUNAB - Aarhus University Network on Artificial Biology

Publications

Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

Sort by: Date | Author | Title

Kofler, R., Langmüller, A. M., Nouhaud, P., Otte, K. A. & Schlötterer, C. (2016). Suitability of different mapping algorithms for genome-wide polymorphism scans with pool-seq data. G3: Genes, Genomes, Genetics, 6(11), 3507-3515. https://doi.org/10.1534/g3.116.034488

Poser, A., Vogt, C., Knoeller, K., Sorokin, D. Y., Finster, K. W. & Richnow, H.-H. (2016). Sulfur and Oxygen Isotope Fractionation During Bacterial Sulfur Disproportionation Under Anaerobic Haloalkaline Conditions. Geomicrobiology Journal, 33(10), 934-941. https://doi.org/10.1080/01490451.2015.1128993

Xia, D., Li, Q., Xue, Q., Liang, C. & Dong, M. (2016). Super flexibility and stability of graphene nanoribbons under severe twist. Physical Chemistry Chemical Physics, 18(27), 18406-18413. https://doi.org/10.1039/c6cp02580c

Sivasundaram, S. & Nielsen, K. H. (2016, Dec 2). Surveying the Attitudes of Physicists Concerning Foundational Issues of Quantum Mechanics. https://arxiv.org/abs/1612.00676

Jørgensen, J. H., Grubisic Cabo, A., Balog, R., Hansen, L. K., Groves, M. N., Cassidy, A. M., Bruix, A., Bianchi, M., Dendzik, M., Arman, M. A., Lammich, L., Pascual, J. I., Knudsen, J., Hammer, B., Hofmann, P. & Hornekaer, L. (2016). Symmetry-Driven Band Gap Engineering in Hydrogen Functionalized Graphene. A C S Nano, 10(12), 10798-10807. https://doi.org/10.1021/acsnano.6b04671

Tian, L., Prabhakaran, M., Hu, J., Chen, M., Besenbacher, F. & Ramakrishnaa , S. (2016). Synergistic effect of topography, surface chemistry and conductivity of the electrospun nanofibrous scaffold on cellular response of PC12 cells. Colloids and Surfaces B: Biointerfaces, 145, 420-429. https://doi.org/10.1016/j.colsurfb.2016.05.032

Niu, L., Liu, L., Xi, W., Han, Q., Li, Q., Yu, Y., Huang, Q., Qu, F., Xu, M., Li, Y., Du, H., Yang, R., Cramer, J., Gothelf, K. V., Dong, M., Besenbacher, F., Zeng, Q., Wang, C., Wei, G. & Yang, Y. (2016). Synergistic Inhibitory Effect of Peptide-Organic Coassemblies on Amyloid Aggregation. A C S Nano, 10(4), 4143-4153. https://doi.org/10.1021/acsnano.5b07396

Wang, Z., Zhao, H., Lv, Y., Xiang, F., Liu, X., Dong, M. & Wang, L. (2016). Synthesis of ordered conjugated polycyclic aromatic hydrocarbon polymers through polymerization reaction on Au(111). Chemical Communications, 52(54), 8420-8423. https://doi.org/10.1039/c6cc01362g

Wang, Z., Chen, Y., Li, P., He, J., Zhang, W., Guo, Z., Li, Y. & Dong, M. (2016). Synthesis of silicon-doped reduced graphene oxide and its applications in dye-sensitive solar cells and supercapacitors. RSC Advances, 6(18), 15080–15086. https://doi.org/10.1039/C5RA25962B

Wei, W., Lu, X., Wang, Z., Dong, M., Feng, F. & Guo, Z. (2016). Synthetic ultra-long chain fatty acyl based amphiphilic lipids as a dual function excipient for the production of surfactant-free solid lipid nanoparticles (SF-SLNs): a physico-chemical study. Green Chemistry, 18(14), 3962-3971. https://doi.org/10.1039/C6GC00866F

Displaying results 1831 to 1840 out of 3467

184

Revised 03.03.2026

-

Kalinka Hansen