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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2015). Opfindelsernes verden. In H. Kragh & K. H. Nielsen (Eds.), 50 opfindelser: Højdepunkter i teknologien (pp. 317-323). Aarhus Universitetsforlag.

Jakob, T., Blank, S. & Spillner, E. (2015). Optimierte Diagnostik der Insektengiftallergie durch rekombinante Allergene. In J. Kleine-Tebbe & T. Jakob (Eds.), Molekulare Allergiediagnostik (pp. 257-275). Springer. https://doi.org/10.1007/978-3-662-45221-9_16

Peng, Z., Hou, X., Mi, J., Liu, L. & Dong, M. (2015). Oxygen reduction reaction on M-S4 embedded graphene: A density functional theory study. Chemical Physics Letters, 641, 112-116. https://doi.org/10.1016/j.cplett.2015.10.067

Neuhaeuser, D., Hirsch, C., Gloaguen, C. & Schmidt, V. (2015). Parametric Modeling of Sparse Random Trees Using 3D Copulas. Stochastic Models, 31(2), 226-260.

Søndergaard, D. & Pedersen, C. N. S. (2015). PATBox: A Toolbox for Classification and Analysis of P-Type ATPases. PLoS One, 10(9), Article e0139571. https://doi.org/10.1371/journal.pone.0139571

Nielsen, K. H. (2015). Peer review. Weekendavisen, Ideer, 10.

Nielsen, K. H. (2015). Peter Pedal i videnskabens tjeneste. Videnskab.dk. http://videnskab.dk/blog/peter-pedal-i-videnskabens-tjeneste

Nielsen, K. H. (2015). Philosophy of citizen science in practice. Abstract from Fifth Biennial Conference of the Society for Philosophy of Science in Practice, Aarhus, Denmark.

Vad, B. S., Balakrishnan, V. S., Nielsen, S. B. & Otzen, D. (2015). Phospholipid Ether Linkages Significantly Modulate the Membrane Affinity of the Antimicrobial Peptide Novicidin. Journal of Membrane Biology, 487-496. https://doi.org/10.1007/s00232-015-9792-y

Panneerselvam, K., Lynge, M. E., Riber, C. F., Mena-Hernando, S., Smith, A. A. A., Goldie, K. N., Zelikin, A. N. & Stadler, B. (2015). Phospholipid-polymer amphiphile hybrid assemblies and their interaction with macrophages. Biomicrofluidics, 9(5), Article 052610. https://doi.org/10.1063/1.4929405

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