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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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Nielsen, K. H. & Klostergaard, L. (2006). N-stråler, vands hukommelse og kold fusion: Naturvidenskabelige begrebers tilblivelse, tilintegørelse og translation. In C. Jantzen & T. Thellefsen (Eds.), Videnskabelig begrebsdannelse (pp. 53-74). Aalborg Universitetsforlag.

Friis, I. & Nielsen, K. H. (2006). Planter, dyr og forskere. In H. Nielsen & K. H. Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie (Vol. 4, pp. 125-146). Aarhus Universitetsforlag.

Nielsen, H. & Nielsen, K. H. (2006). Populærvidenskab fra forsker til folk. In H. Nielsen & K. H. Nielsen (Eds.), Viden uden grænser 1920-1970: Dansk Naturvidenskabs Historie (Vol. 4, pp. 383-404). Aarhus Universitetsforlag.

Mailund , Brodal, G. S., Fagerberg, R., Pedersen, C. N. S. & Phillips, D. (2006). Recrafting the Neighbor-Joining Method. BMC Bioinformatics, 7(29).

Frandsen, J., Hobolth, A., Østergaard, L., Vestergaard-Poulsen, P. & Vedel, E. B. (2006). Regularization of Diffusion Tensor Fields in Axonal Fibre Tracking. Poster session presented at PhD Day 2006, The Faculty of Health Sciences, Aarhus, Denmark.

Howard, K. A., Rahbek, U. L., Liu, X., Damgaard, C. K., Glud, S. Z., Andersen, M. Ø., Hovgaard, M. B., Schmitz, A., Nyengaard, J. R., Besenbacher, F. & Kjems, J. (2006). RNA interference in Vitro and in Vivo using a novel chitosan/siRNA nanoparticle system. Molecular Therapy, 14(4), 476-484. https://doi.org/10.1016/j.ymthe.2006.04.010

Dong, M. (2006). Scanning probe microscopy studies of biomolecules on surfaces. Interdisciplinary Nanoscience Center (iNANO).

Birkedal, V., Krüger, A., Raarup, M. K., Kristensen, M., Kjems, J. & Besenbacher, F. (2006). Single molecule FRET microscopy on G-quadruplex DNA structures. Poster session presented at Single Molecule Picoquant Workshop, Berlin, Germany.

Krüger, A., Birkedal, V., Raarup, M. K., Kristensen, M., Kjems, J. & Besenbacher, F. (2006). Single-molecule Microscopy on Nucleic Acids. Poster session presented at NANOBIO Summer School "The live cell from nano to micro", Cargese, Corse, France.

Kjems, J. & Wengel, J. (2006). Small internally segmented interfering RNA.

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