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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Hobolth, A. & Siren, J. (2016). The multivariate Wright–Fisher process with mutation: Moment-based analysis and inference using a hierarchical Beta model. Theoretical Population Biology, 108, 36-50. https://doi.org/10.1016/j.tpb.2015.11.001

Jarvela, T. S., Lam, H. A., Helwig, M., Lorenzen, N., Otzen, D. E., McLean, P. J., Maidment, N. T. & Lindberg, I. (2016). The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity. Proceedings of the National Academy of Sciences (PNAS), 113(32), E4708-E4715. https://doi.org/10.1073/pnas.1601091113

Nielsen, K. H. (2016). The practice and politics of integrated science teaching in the global Cold War. RePoSS: Research Publications on Science Studies Vol. 35 http://css.au.dk/fileadmin/reposs/reposs-035.pdf

Li, D., Dong, MD., Besenbacher, F., Huang, Y. & Chen, M. (2016). The preparation of a recyclable catalyst of silver nanoparticles dispersed in mesoporous silica nanofiber matrix. RSC Advances, 6(70), 65613 - 65618. https://doi.org/10.1039/C6RA10867A

Li, D., Dong, MD., Besenbacher, F., Huang, Y. & Chen, M. (2016). The preparation of a recyclable catalyst of silver nanoparticles dispersed in mesoporous silica nanofiber matrix. Journal of Biotechnology & Biomaterials, 6(3(Suppl)), 40-40. https://doi.org/10.4172/2155-952X.C1.052

Vu-Quang, H., Vinding, M. S., Nielsen, T., Ullisch, M. G., Nielsen, N. C. & Kjems, J. (2016). Theranostic Tumor Targeted Nanoparticles Combining Drug Delivery with Dual Near Infrared and (19)F Magnetic Resonance Imaging Modalities. Nanomedicine: Nanotechnology, Biology and Medicine, 12(7), 1873-1884. https://doi.org/10.1016/j.nano.2016.04.010

Ling, M., Santl-Temkiv, T., Holm, S., Finster, K. & Boesen, T. (2016). The role of ice nucleation protein in active atmospheric dissemination of P. syringae. Poster session presented at ISME Conference 2016, Montreal, Canada.

Agerschou, E. D., Christiansen, G., Schafer, N. P., Madsen, D. J., Brodersen, D. E., Semsey, S. & Otzen, D. E. (2016). The transcriptional regulator GalR self-assembles to form highly regular tubular structures. Scientific Reports, 6, Article 27672. https://doi.org/10.1038/srep27672

Xia, D., Zhang, S., Nielsen, E., Ivarsen, A. R., Liang, C., Li, Q., Thomsen, K., Hjortdal, J. Ø. & Dong, M. (2016). The Ultrastructures and Mechanical Properties of the Descement's Membrane in Fuchs Endothelial Corneal Dystrophy. Scientific Reports, 6, Article 23096. https://doi.org/10.1038/srep23096

Taskin, M. B., Xu, R., Gregersen, H. V., Nygaard, J. V., Besenbacher, F. & Chen, M. (2016). Three-dimensional polydopamine functionalized coiled microfibrous scaffolds enhance human mesenchymal stem cells colonization and mild myofibroblastic differentiation. A C S Applied Materials and Interfaces, 8(25), 15864–15873. https://doi.org/10.1021/acsami.6b02994

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Kalinka Hansen