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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Berné, O., Habart, É., Peeters, E., Abergel, A., Bergin, E. A., Bernard-Salas, J., Bron, E., Cami, J., Dartois, E., Fuente, A., Goicoechea, J. R., Gordon, K. D., Okada, Y., Onaka, T., Robberto, M., Röllig, M., Tielens, A. G. G. M., Vicente, S., Wolfire, M. G. ... Zhen, J. (2022). PDRs4All: A JWST Early Release Science Program on Radiative Feedback from Massive Stars. Publications of the Astronomical Society of the Pacific, 134(1035), Article 054301. https://doi.org/10.1088/1538-3873/ac604c

Basse Eriksen, C. (2022). Peber, ingefær, nelliker og muskatnød: Koloniale materialer og naturhistorisk ekspertise i Antoni van Leeuwenhoeks mikroskopiske observationer. Slagmark: tidsskrift for idéhistorie , 84, 15-35. https://tidsskrift.dk/slagmark/article/view/149713/192525

Hirsch, C., Jahnel, B. & Cali, E. (2022). Percolation and connection times in multi-scale dynamic networks. Stochastic Processes and Their Applications, 151, 490-518. https://doi.org/10.1016/j.spa.2022.06.008

Bak, E. N., Nornberg, P., Jensen, S. J. K., Thogersen, J. & Finster, K. (2022). Physical and chemical mechanisms that impact the detection, identification, and quantification of organic matter and the survival of microorganisms on the Martian surface - a review. International Journal of Astrobiology, 21(5), 356-379. Article 1473550421000392. https://doi.org/10.1017/S1473550421000392

Eriksen, C. B. (2022). Picturing Seeds of Poppies: Microscopes, Specimens, and Representation in Seventeenth-Century English Botany. Nuncius, 37(2), 346-373. https://doi.org/10.1163/18253911-bja10023

Alam, P., Holst, M. R., Lauritsen, L., Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R., Otzen, D. E. & Nielsen, M. S. (2022). Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers. Fluids and Barriers of the CNS, 19(1), Article 37. https://doi.org/10.1186/s12987-022-00334-y

Ade, C., Qian, X., Brodszkij, E., De Dios Andres, P., Spanjers, J., Westensee, I. N. & Städler, B. (2022). Polymer Micelles vs Polymer-Lipid Hybrid Vesicles: A Comparison Using RAW 264.7 Cells. Biomacromolecules, 23(3), 1052-1064. https://doi.org/10.1021/acs.biomac.1c01403

Truong, T. T., Hayn, M., Frich, C. K., Olari, L.-R., Ladefoged, L. K., Olesen, M. T. J., Jakobsen, J. H., Lunabjerg-Vestergaard, C. K., Schiøtt, B., Münch, J. & Zelikin, A. N. (2022). Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells. Advanced Therapeutics, 5(11), Article 2200113. https://doi.org/10.1002/adtp.202200113

Li, Z., Liu, Q., Zhang, D., Wang, Y., Zhang, Y., Li, Q. & Dong, MD. (2022). Probing the hydration friction of ionic interfaces at the atomic scale. Nanoscale Horizons, 7(4), 368-375. https://doi.org/10.1039/d1nh00564b

Li, C., Zhang, X., Dong, M. & Han, X. (2022). Progress on Crowding Effect in Cell-like Structures. Membranes, 12(6), Article 593. https://doi.org/10.3390/membranes12060593

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Kalinka Hansen