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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

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Majidi, S. S., Su, Y., Jørgensen, M. L., Müller, C., Forooghi, P., Nie, G. & Chen, M. (2021). Rayleigh Instability-Driven Coaxial Spinning of Knotted Cell-Laden Alginate Fibers as Artificial Lymph Vessels. ACS applied materials & interfaces, 13(19), 22142-22149. https://doi.org/10.1021/acsami.1c00798

Qin, T., Wang, Z., Wang, Y., Besenbacher, F., Otyepka, M. & Dong, M. (2021). Recent Progress in Emerging Two-Dimensional Transition Metal Carbides. Nano-Micro Letters, 13(1), Article 183. https://doi.org/10.1007/s40820-021-00710-7

Nielsen, K. H. (2021). Rene hænder. Weekendavisen, (Sektion 4 (Ideer)), 5. https://www.weekendavisen.dk/2021-42/ideer/rene-haender

Pedersen, B. H., Malte, H., Finster, K. & Ramløv, H. (2021). Respiration Measurements of Individual Tardigrades of the Species Richtersius cf coronifer as a Function of Temperature and Salinity and Termination of Anhydrobiosis. Astrobiology, 21(7), 853-865. https://doi.org/10.1089/ast.2020.2371

Vandestadt, C., Vanwalleghem, G. C., Khabooshan, M. A., Douek, A. M., Castillo, H. A., Li, M., Schulze, K., Don, E., Stamatis, S. A., Ratnadiwakara, M., Änkö, M. L., Scott, E. K. & Kaslin, J. (2021). RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish. Developmental Cell, 56(16), 2364-2380.e8. https://doi.org/10.1016/j.devcel.2021.07.021

Geary, C., Grossi, G., McRae, E. K. S., Rothemund, P. W. K. & Andersen, E. S. (2021). RNA origami design tools enable cotranscriptional folding of kilobase-sized nanoscaffolds. Nature Chemistry, 13(6), 549-558. https://doi.org/10.1038/s41557-021-00679-1

Decuzzi, P., Peer, D., Di Mascolo, D., Palange, A. L., Manghnani, P. N., Moein Moghimi, S., Shadi Farhangrazi, Z., Howard, K. A., Rosenblum, D., Liang, T., Chen, Z., Wang, Z., Zhu, J. J., Gu, Z., Korin, N., Letourneur, D., Chauvierre, C., van der Meel, R., Kiessling, F. & Lammers, T. (2021). Roadmap on nanomedicine. Nanotechnology, 32(1), Article 012001. https://doi.org/10.1088/1361-6528/abaadb

Wang, Y., Skaanvik, S. A., Xiong, X., Wang, S. & Dong, M. (2021). Scanning probe microscopy for electrocatalysis. Matter, 4(11), 3483-3514. https://doi.org/10.1016/j.matt.2021.09.024

Nielsen, K. H. (2021). Science and public policy. Metascience, 30(1), 79-81. https://doi.org/10.1007/s11016-020-00581-5

Wang, Z., Xiong, X., Li, J. & Dong, M. (2021). Screening fermi-level pinning effect through van der waals contacts to monolayer MoS₂. Materials Today Physics, 16, Article 100290. https://doi.org/10.1016/j.mtphys.2020.100290

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