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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Song, Y., Dai, B., Wang, Y., Wang, Y., Gourdon, P., Liu, L., Wang, K. & Dong, M. (2022). Identifying Heterozipper β-Sheet in Twisted Amyloid Aggregation. Nano Letters, 22(9), 3707-3712. https://doi.org/10.1021/acs.nanolett.2c00596

Rasmussen, H. Ø., Otzen, D. E. & Pedersen, J. S. (2022). Induction, inhibition, and incorporation: Different roles for anionic and zwitterionic lysolipids in the fibrillation of the functional amyloid FapC. The Journal of Biological Chemistry, 298(2), Article 101569. https://doi.org/10.1016/j.jbc.2022.101569

Zhang, M., Zhang, Y., Mu, W., Dong, M. & Han, X. (2022). In Situ Synthesis of Lipid Analogues Leading to Artificial Cell Growth and Division. ChemSystemsChem, 4(4), Article 202200007. https://doi.org/10.1002/syst.202200007

Najarzadeh, Z., Mohammad-Beigi, H., Pedersen, J. N., Christiansen, G., Pedersen, J. S., Nielsen, J. & Otzen, D. E. (2022). Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation. BBA advances, 2, Article 100055. https://doi.org/10.1016/j.bbadva.2022.100055

Zhu, X., Wang, Z., Hu, J., Lu, Z., Gao, M., Wang, Y., Song, Z., Dong, M., Wang, Z. & Klausen, L. H. (2022). Ion-modulated photoluminescence of MoS₂ nanoflakes for cell viability detection. New Journal of Chemistry, 46(46), 22441-22450. https://doi.org/10.1039/d2nj04073e

Nielsen, K. H. (2022). Kræftfremkaldende babypudder. Weekendavisen, Sektion 4 (Ideer), 13.

Nielsen, K. H. (2022). Læk fra laboratoriet. Weekendavisen, Sektion 4 (Ideer), 5.

Eriksen, C. B. (2022). Leeuwenhoek, Antoni van. In D. Jalobeanu & C. T. Wolfe (Eds.), Encyclopedia of Early Modern Philosophy and the Sciences (pp. 1068-1070). Springer.

Reimer, L., Haikal, C., Gram, H., Theologidis, V., Kovacs, G., Ruesink, H., Baun, A., Nielsen, J., Otzen, D. E., Li, J.-Y. & Jensen, P. H. (2022). Low dose DMSO treatment induces oligomerization and accelerates aggregation of α-synuclein. Scientific Reports, 12, Article 3737. https://doi.org/10.1038/s41598-022-07706-2

Groß, R., Dias Loiola, L. M., Issmail, L., Uhlig, N., Eberlein, V., Conzelmann, C., Olari, L. R., Rauch, L., Lawrenz, J., Weil, T., Müller, J. A., Cardoso, M. B., Gilg, A., Larsson, O., Höglund, U., Pålsson, S. A., Tvilum, A. S., Løvschall, K. B., Kristensen, M. M. ... Münch, J. (2022). Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2. Advanced Science, 9(20), Article 2201378. https://doi.org/10.1002/advs.202201378

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Kalinka Hansen