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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Ng, C., Samanta, A., Mandrup, O. A., Tsang, E., Youssef, S. Y. E. K., Klausen, L. H., Dong, MD., Nijenhuis, M. A. D. & Gothelf, K. V. (2023). Folding double-stranded DNA into designed shapes with triplex-forming oligonucleotides. https://doi.org/10.26434/chemrxiv-2022-rt0tw-v2

Ng, C., Samanta, A., Mandrup, O. A., Tsang, E., Youssef, S., Klausen, L. H., Dong, M., Nijenhuis, M. A. D. & Gothelf, K. V. (2023). Folding Double-Stranded DNA into Designed Shapes with Triplex-Forming Oligonucleotides. Advanced Materials, 35(40), Article 2302497. https://doi.org/10.1002/adma.202302497

Nielsen, K. H. (2023). Folkedrab eller hungersnød. Weekendavisen, Sektion 4 (Ideer), 5.

Nielsen, K. H. (2023). Folkedrabet i Namibia. Weekendavisen, Sektion 4 (Ideer), 5.

Rasmussen, A. P., Wenzel, G., Hornekær, L. & Andersen, L. H. (2023). Gas-phase electronic action absorption spectra of protonated oxygen-functionalized polycyclic aromatic hydrocarbons (OPAHs). Astronomy and Astrophysics, 674, Article A103. https://doi.org/10.1051/0004-6361/202346003

Jaganathan, R., Tang, Z., Simonsen, F. D. S., Palotás, J., Oomens, J., Hammer, B. & Hornekær, L. (2023). Gas Phase IR Spectra of Hydrogen Functionalised Pentacene. In V. Mennella & C. Joblin (Eds.), European Conference on Laboratory Astrophysics ECLA2020: The Interplay of Dust, Ice, and Gas in Space (pp. 209-214). Springer. https://doi.org/10.1007/978-3-031-29003-9_23

Gao, P., Zhang, X., Huang, X., Chen, Z., Marietou, A., Holmkvist, L., Qu, L., Finster, K. & Gong, X. (2023). Genomic insight of sulfate reducing bacterial genus Desulfofaba reveals their metabolic versatility in biogeochemical cycling. BMC Genomics, 24(1), Article 209. https://doi.org/10.1186/s12864-023-09297-2

Evans, D. C. S., Khamas, A. B., Marcussen, L., Rasmussen, K. S., Klitgaard, J. K., Kallipolitis, B. H., Nielsen, J., Otzen, D. E., Leake, M. C. & Meyer, R. L. (2023). GFP fusions of Sec-routed extracellular proteins in Staphylococcus aureusreveal surface-associated coagulase in biofilms. Microbial Cell, 10(7), 145-156. https://doi.org/10.15698/mic2023.07.800

Xu, R., Gao, J., Cao, C., Shi, M., Zhang, Y., Hong, S., Guo, S., Chen, M., Song, P., Fu, G., Li, J., Liang, T., Miao, Y., Tang, L., Yang, J., Li, N. & Dong, M. (2023). HDL mimetics protect Alzheimer's patients carrying APOE ε4 from SARS-CoV-2 invasion. Nano Today, 53, Article 102051. https://doi.org/10.1016/j.nantod.2023.102051

Zhou, X., Rahimi, K., Kjems, J. & Lin, L. (2023). High-resolution RNA isoform variation analysis by combining the advantages of single-cell RNA and nanopore sequencing. 44. Abstract from Neuroscience Day, Aarhus, Denmark.

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Kalinka Hansen