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AUNAB - Aarhus University Network on Artificial Biology

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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Cui, L., Fang, Z., Liu, Y., Chen, M., Yin, C., Wang, J., Wang, Z., Dong, M., Kang, S. & Liu, P. (2019). Moderate NaNO ₂ etching enables easy crystallinity optimization of g-C ₃ N ₄ with superior photoreduction performance. Inorganic Chemistry Frontiers, 6(5), 1304-1311. https://doi.org/10.1039/c9qi00113a

Zhang, P., Wang, Z., Liu, L., Klausen, L. H., Wang, Y., Mi, J. & Dong, M. (2019). Modulation the electronic property of 2D monolayer MoS₂ by amino acid. Applied Materials Today, 14(March), 151-158. https://doi.org/10.1016/j.apmt.2018.12.003

Poghosyan, A. H., Schafer, N., Lyngsø, J., Shahinyan, A. A., Pedersen, J. S. & Otzen, D. (2019). Molecular dynamics study of ACBP denaturation in alkyl sulfates demonstrates possible pathways of unfolding through fused surfactant clusters. Protein Engineering, Design and Selection, 32(4), 175-190. Article gzz037. https://doi.org/10.1093/protein/gzz037

Zhang, X., Zong, W., Wang, J., Dong, M., Cheng, W., Sun, T. & Han, X. (2019). Multicompartmentalized vesosomes containing DOX loaded liposomes and 5FU loaded liposomes for synergistic tumor treatment. New Journal of Chemistry, 43(12), 4895-4899. https://doi.org/10.1039/c9nj00238c

Cui, H., Chen, X., Bai, M., Han, D., Lin, L. & Dong, M. (2019). Multipathway Antibacterial Mechanism of a Nanoparticle-Supported Artemisinin Promoted by Nitrogen Plasma Treatment. ACS Applied Materials & Interfaces, 11(50), 47299-47310. https://doi.org/10.1021/acsami.9b15124

Basse-O'Connor, A., Nielsen, M. S., Pedersen, J. & Rohde, V. U. (2019). Multivariate stochastic delay differential equations and CAR representations of CARMA processes. Stochastic Processes and Their Applications, 129(10), 4119-4143. https://doi.org/10.1016/j.spa.2018.11.011

Yang, Q., Dong, L., Su, R., Hu, B., Wang, Z., Jin, Y., Wang, Y., Besenbacher, F. & Dong, M. (2019). Nanostructured heterogeneous photo-catalysts for hydrogen production and water splitting: A comprehensive insight. Applied Materials Today, 17, 159-182. https://doi.org/10.1016/j.apmt.2019.07.016

Nielsen, K. H. (2019). Naturkatastrofe. Weekendavisen, Sektion 4 (Ideer), 10.

Juul, M., Madsen, T., Guo, Q., Bertl, J., Hobolth, A., Kellis, M. & Pedersen, J. S. (2019). ncdDetect2: Improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation. Bioinformatics, 35(2), 189-199. https://doi.org/10.1093/bioinformatics/bty511

Knudsen, L. J., Nielsen, S. D.-H., Rauh, V., Otzen, D. & Larsen, L. B. (2019). New Lactase Enzymes. Abstract from Sandbjerg Seminar 2019, Sønderborg, Denmark.

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Kalinka Hansen