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Recent research news on Artificial Biology

Distinct Network Morphologies from In Situ Polymerization of Microtubules in Giant Polymer-Lipid Hybrid Vesicles

Creating artificial cells with a dynamic cytoskeleton, akin to those in living cells, is a major goal in bottom-up synthetic biology. In this study, we demonstrate the in situ polymerization of microtubules encapsulated in giant polymer-lipid hybrid vesicles (GHVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine and an amphiphilic block copolymer. The block copolymer is comprised of poly(cholesteryl methacrylate-co-butyl methacrylate) as the hydrophobic block and either poly(6-O-methacryloyl-D-galactopyranose) or poly(carboxyethyl acrylate) as the hydrophilic extension. Depending on the concentrations of guanosine triphosphate (GTP) or its slowly hydrolyzable analog, guanosine-5′-[(α,β)-methyleno]triphosphate (GMPCPP), different microtubule morphologies are observed, including encapsulated microtubule networks, spike protrusions, as well as membrane-associated or aggregated microtubules. Overall, this work represents a step forward in mimicking the cellular cytoskeletons and uncovering the influence of membrane composition on microtubule morphologies.

Recent publications by network

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Nielsen, K. H. (2020). Science communication from the perspective of STS. In A. Turanlı, A. U. Aydınoğlu & M. Şahinol (Eds.), Türkiye’de STS: bilim ve teknoloji Çalışmalarına giriş (pp. 37-47). İstanbul Teknik Üniversitesi. http://hdl.handle.net/11527/18483

Krainer, G., Hartmann, A., Bogatyr, V., Nielsen, J., Schlierf, M. & Otzen, D. E. (2020). SDS-induced multi-stage unfolding of a small globular protein through different denatured states revealed by single-molecule fluorescence. Chemical Science, 11(34), 9141-9153. https://doi.org/10.1039/d0sc02100h

Li, C. H., Prokopec, S. D., Sun, R. X., Yousif, F., Schmitz, N., PCAWG Tumour Subtypes and Clinical Translation, Boutros, P. C. & PCAWG Consortium (2020). Sex differences in oncogenic mutational processes. Nature Communications, 11, Article 4330. https://doi.org/10.1038/s41467-020-17359-2

Chen, M. (2020). She’s injecting ‘solar cells’ into the body to regenerate brain cells. In J. Bruun (Ed.), Profile 2020 (pp. 70-73). Aarhus Universitet, Institut for Ingeniørvidenskab . https://www.e-pages.dk/aarhusuniversitet/2231/html5/

Nielsen, K. H. (2020). Singularitet. Weekendavisen, (Sektion 4 (Ideer)), 10.

Juul-Madsen, K., Qvist, P., Bendtsen, K. L., Langkilde, A. E., Vestergaard, B., Howard, K., Dehesa-Etxebeste, M., Paludan, S. R., Andersen, G. R., Jensen, P. H., Otzen, D. E., Romero-Ramos, M. & Vorup-Jensen, T. (2020). Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4. Journal of Immunology, 204(5), 1345-1361. https://doi.org/10.4049/jimmunol.1900494

Giglio, L. P., Picheth, G. F., Løvschall, K. B., Zelikin, A. N. & de Oliveira, M. G. (2020). S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response. Nitric Oxide: Biology and Chemistry, 98, 41-49. https://doi.org/10.1016/j.niox.2020.03.002

Cockell, C. S., Santomartino, R., Finster, K., Waajen, A. C., Eades, L. J., Moeller, R., Rettberg, P., Fuchs, F. M., Van Houdt, R., Leys, N., Coninx, I., Hatton, J., Parmitano, L., Krause, J., Koehler, A., Caplin, N., Zuijderduijn, L., Mariani, A., Pellari, S. S. ... Demets, R. (2020). Space station biomining experiment demonstrates rare earth element extraction in microgravity and Mars gravity. Nature Communications, 11, Article 5523. https://doi.org/10.1038/s41467-020-19276-w

Kristensen, L. S., Ebbesen, K. K., Sokol, M., Jakobsen, T., Korsgaard, U., Eriksen, A. C., Hansen, T. B., Kjems, J. & Hager, H. (2020). Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. Nature Communications, 11, Article 4551. https://doi.org/10.1038/s41467-020-18355-2

Nielsen, K. H. (2020). Sprogforvirring. Weekendavisen, (Sektion 4 (Ideer)), 5.

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